Expression Of Matrix Metalloproteinases And Tissue Inhibitors Of Metalloproteinases Of Chronic Allograft Nephropathy

Objective Renal transplantation is an effective therapy for end stage renal disease(ESRD). In recent years, with the development of matching technique, immunosuppressive agents and surgical technique, the incidence of acute rejection episodes has decreased significantly,short-term survival rates of recipients have increased evidently, and 1-year survival rates of recipients has arrived to 90% or more. While there has no significant increase for the half life and long-term survival rate of graft, because of chronic allograft nephropathy(CAN). We established a rat model of CAN, and detect the expression of matrix metalloproteinase-2/-9(MMP-2/-9) and tissue inhibitors of metalloprotemase-1/-2(TIMP-1/-2) in allograft through it. This study will also investigate the effect of different immunosuppresants on CAN by affecting MMPs/TIMPs.Methods The closed colony strain rats SD as well as Wistar were used as donor and recipient, respectively. Orthotopic kidney transplantation was...