Cardiopretective Effects Of Preconditionning With Isoflurane Or Sevoflurtane In Patients Undergoing Coronay Artery Bypass Graft Surgery Under Cardiopulmonary Bypass

Objective : To investigate the cardiopretective effects and the mechanism of preconditioning with isoflurane or sevoflurane .Methods :Thirty-nine ASA II-III(26 male, 23 female) aged 40-75 patients scheduled for elective coronary artery bypass graft (CABG) surgery were randomly divided into three groups of 13 patients : isoflurane group (A), sevoflurane group (B) and control group (C). In group A and group B, the vaporizer was adjusted lvol %-2vol% from the beginning of operation to the beginning of CPB, and before clamping , the vaporizer was shut off and the end-tidal concertration was decreased to 0. The central venous blood samples were collected for the measurements of creatine kinase (CK-MB), cTnI, superoxide dismutase (SOD) and malondialdehyde (MDA) before anesthesia(T₁), 15 min after release of aortic cross-clamp(T2),immediately after operation (T₃) and3h (T₄)24h (T₅) after operation. HR, MAP, PAP, CVP, CO and SVR were recorded before skin incision (t₁), before CPB (t₂), 15 min after CPB (t₃) and immediately after operation (t₄).Results : At each period of time after reperfussion,compared with T₁, the contents of CK-MB and cTnI in all of the three groups increased significantly (p＜0.01.). But comparede with group C, the content of CK-MB and CtnI were significantly lower in group A and group B (p<0.01).