Retrospective Analysis On Hypertension Correlated With Immunosuppressive Drugs In Liver Transplant Recipients

Objective : Liver transplant recipients display a high hypertension morbidity rate, Our goal is to study the variance and characteristic of blood pressure (BP) in the liver transplant recipients.Methods : 206 patients in our hospital from February 2001 to July 2005 were included in a retrospective descriptive study. The BP level, serum immunosuppressant concentration and some biochemical parameters (creatinine-Cr, blood urea nitrogen-BUN, totle cholesterol-TC, uric acid-UA, triglyceride-TG) were determined.Results : Compared with the preoperation, the average systolic and diastolic pressure rose obviously at the time of 2 week and 1, 2, 4 and 6 month. The morbidity of hypertension went up obviously after liver transplantation, with the highest morbidity 46.49% at the 1st month. The character of hypertension was the elevating of systolic pressure as well as diastolic pressure. There was no linear correlation between the immunosuppressant (FK506) concentration and the BP level at any point, as well as those biochemical parameters. But compared with the time of 2 week, the serum TC and UA level rose obviously at all the later time. Furthermore, there was an upward trend in some biochemical parameterssuch as TC, UA and Cr.Conclusion : There was a high hypertension morbidity after liver transplantation, and the character of hypertension was the elevating of systolic pressure as well as diastolic pressure. Although the use of immunosuppressive drugs accompanied with the BP rose, there was no linear correlation between the immunosuppressant concentration and the BP level. The serum TC , UA and Cr level will also go up by using immunosuppressants.