| Objective To analyze the effect of FLAG regimen in the treatment of relapsed/refractory acute myeloid leukemia and investigate the time of bone marrow suppression and its toxicity. Methods Patients received daily intravenous infusion of fludarabine (30mg/m~2/d over 30min) and Ara-C(2g/m~2/d over 4h) for 5d.Subcutaneous injections of G-CSF (300μg/d) were given, starting 1d prior to chemotherapy and continuing until leucocyte over 2000/ μL. Results Four of the six patients with relapsed/refractory acute myeloid leukemia achieved CR and two were noneffective. The CR rate was 66.7%. One of the CR patients prepared to receive allogeneic hematopoietic stem-cell transplantation, and three of them kept CR after receiving consolidation treatment, such as FLAG regimen and AA regimen. Its toxicity was mainly bone marrow suppression. One patient with hepatitis got hepatic damage and other toxicities were unconspicuous. Conclusion The FLAG regimen is effective and it is well tolerated by most patients. So it offers a very effectivealternative treatment for CR induction in patients with relapsed/refractory acutemyeloid leukemia and also offers an opportunity for hematopoietic stem-celltransplantation. |
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