Obstructive Sleep Apnea-hypopnea Syndrome(OSAHS) Is Independently Associated With The Metabolic Syndrome(MS)

objective:obstructive sleep apnea-hypopnea syndrome(OSAHS) is characterised by repeated episodes of apnoea and hypopnoea during sleep . It was previously assumed that this occurred because of the related obesity, recent data suggest that OSAHS is independently associated with the cardiovascular risk factors that comprise metabolic syndrome, including hypertension, insulin resistance, high glucose, and dyslipidaemia. However, most of previous studies have only considered these variables individually, to test the overall association of OSAHS with this syndrome, we measured blood pressure, fasting glucose, fasting insulin, insulin resistance, fasting lipids, and the prevalence of metabolic syndrome. Methods:Through polysomnography examination ,82 obesity were divided into OSAHS group (obesity with OSAHS group )and without OSAHS group(obesity without OSAHS group ), and 30 normal weight subjects as the control group OSAHS Was defined as an apnea-hypopnea index(AHI)≥5. The obesity were measured polysomnography parameters such as AHI, SpO2 . ALL cases were measured MS-associated parameters such as fasting blood glucose ( FBG) , total cholesterol ( TC), triglyceride ( TG), highdensity lipoprotein cholesterol ( HDL-C) ,low-density lipoprotein cholesterol (LDL-C) ,insulin homeostasis model assessment (HOMA) index and blood pressure (BP) ,as well as body mass index (BMI) ,waist circumference and neck circumference . The incidences of MS were compared among different groups. The correlations between them were analyzed. Results:The incidence of MS in obesity with OSAHS group was significantly higher than that in obesity without OSAHS group (60% vs 25.93%, p<0.005) subjects with OSAHS had higher SBP and DBP, higher fasting blood glucose and HOMA index than obesity without OSAHS group. Multiple linear regression showed SpO₂ was the independent determinants of DBP, AHI were the independent determinants of FINS and HOMA index. Condusion:OSAHS is independently associated with an increase in the cardiovascular risk factors that comprise the metabolic syndrome and its overall prevalence.