The Expressions Of Survivin, MMP-9 And Their Clinicopathologoical Significance In Colorectal Carcinogenesis

Objective: To study the expressions of Survivin and MMP-9 incarcinogenesis of colorectal adenoma for investigating their roles in pathogenesis, progression, invasion and metastasis of colorectal carcinoma and their correlation and aiding in clinicopathological diagnosis and evaluation of prognosis.Methods: The expressions of Survivin and MMP-9 were detected in 12 casesof normal colorectal mucosa,35 cases of colorectal adenoma with low-grade dysplasia and high-grade dysplasia and 59 cases of colorectal carcinoma by SABC technique of immunohistochemistry and in situ hybridization.Results: (1) Survivin protein was localized in cytoplasma of adenoma andcarcinoma cells with mild to severe intensity. The positive rates of Survivin protein were 25%, 28.6%, 64.3% and 71.2% in the groups of normal mucosa, colorectal adenoma with low-grade dysplasia, colorectal adenoma with high-grade dysplasia and colorectal carcinoma respectively. The immunoreactivity of Survivin increased gradually in the transition from colorectal adenoma to carcinoma. There was significance between the groups of normal mocosa, adenoma with low-grade dysplasia , and the groups of adenoma with high-grade dysplasia, colorectal carcinoma (p<0.05). There was no significance between the groups of colorectal adenoma with high-grade dysplasia and colorectal carcinoma(p>0.05). The expression of Survivin in colorectal carcinoma showed no obvious correlations with tumor size, tumor invasive depth, histological differentiation, Duckes stage and lymph node...