Relationship Between Brain Edema Around Hematoma And The Changes Of Serum Inflammatory Cytokines In Patients With Intracerebral Hemorrhage

Objectives: Intracerebral hemorrhage means non-traumatic parenchymal hemorrhage and is associated with extremely high rate of mortality and morbidity. It accounts for 10% to 30% of all strokes. Currently, no definite treatment is available for ICH. A poor understanding of the pathophysiologic process underlying neuronal injury after ICH is responsible for the lack of effective therapies. Most researchers believe that the secondary injury around hematoma is the main cause which leads to the deterioration of nerve function. The most important pathophysiologic change is the secondary brain edema following ICH. The reason of brain edema formation is very complex. Hemoglobin release after erythrocyte cytolysis in the hematoma and inflammatory cytokines participation may be important reasons in the brain edema formation after ICH. Cytokins are basic meditors of immunity, and involed the inflammatory cells activation and infiltration. The functions of cytokins are great complicated in vivo, affect each other in their induction, regulation of receptor, and exertion of...