Study On Using Of Rabies Vaccine And Interferon-alpha 2b For Anti-Rabies

Objective : as a major rabies vaccine for the treatment of post-exposure immunization vaccines, immunization and rapidly produce high titer antibody and cellular immune good to play a crucial role in the prevention of rabies. The current market is mainly used their Vero cell rabies vaccine is a vaccine adjuvant Al delay it produce antibodies and cellular immunity inhibition characteristics, combined with IFN-α2b rabies vaccine to improve early neutralizing antibody titer and the level of immune cells in a very important significance. In this paper, Vero rabies vaccine combined with IFN-α2b measured in animal experiments and experimental crowd of immunity, and a preliminary discussion of procedures and immunization dose.Methods : The Vero cell rabies vaccine experiments with IFN-alpha-2b combined with a separate application for the control of rabies vaccine, immunization experiments, animals and observe the immune effect of the crowd. 1. To observe the cellular immune level, we have adopted a rabies vaccine and interferon-alpha 2b combined 0, 7 days intraperitoneal injection of BALB mice (rabies vaccine 0.5ml, IFN-α2b1500IU), while another simple application of rabies vaccine group and the control group, 15 days after the mice were killed doing the following experiment : [1] spleen lymphocyte proliferation and transformation experiments[2]murine T lymphocyte surface markers Flow Detection : CD4+, CD8+ Detection and CD4+...