Prognostic Factors For Patients With Astroglioma And Set Up COX's Proportional-Hazards Model

Objective To explore theprognostic factors of astrocytic tumors as the theoretical reference to the clinicaltreatment.Methods Data of 109 patients with astrocytic tumors, admitted in our Hospital from 1996 to 2006, were collected and analyzed with regard to patients's age, gender, preoperative KPS score, histologic grade, tumor location and extension, the contrast enhancement of lesion on MRI, extent of surgery, radiation, date of operation, date of death, physical state in the last follow-up (dead or alive), and cause of death. For the univariate analysis, survival probabilities were estimated based on Kaplan-Meiers survival analysis and Log rank test. Multivariate regression analysis using Cox's proportional-hazards model showed the simultaneous effect of outcome-related variables on survival.Results Univariate analysis demonstrated that patient age, the contrast enhancement of lesion on MRI , KPS score, epilepsy before surgery, histologic grade and radiation were the significant factors for survival (P<0.01). In contrast, multivariate survival analysis showed that patient age, histologic grade, extent of sugery , postoperative radiation and KPS score were independent, statistically significant prognostic factors for patients with astrocytic tumors. And gender, tumor location, tumor extension and had no association with patientsurvivalon both...