Study On Pharmacokinetics About The Ultra Powder Of Ermiao Pellet, Strychnos Nux-comica L And So On Chinese Herbs

The technology of ultra powder turning up and developing in recent years, turns to special mechanical force, stream force, and physcial or chemical action to ultra grind general substance. Not changing their chemical components, it changes their surface and interface to some fancy changes.When used, ultra powder can come into supernormal effects exceeding general powder.In order to know about physcial and chemical character of ultra powder,we make use of scanning electron microscope, biological microscopic identification, granularity, bulk density, special surface area measurement and so on, to characterize the ultra powder and general powder of Chinese herbs.The results indicate that after Chinese herbs has been ultra ground, the sizes of grains are even, the bulk density increase notably, and the special surface area are also greatly enhanced. By microscopic identification, most cells of samples are broken, and available composition can be exposed well without transmural release as usual, with greatly enhanced bioavailability.Solution speed of available composition of Chinese herbs, usually relates to the degree of fineness improved, and speed raised , clinical curative effects can be greatly enhanced. In order to study the effects of degree of fineness and granularity of pellets itself on solution speed of pellets, the test employ spectrophotometer to measure and compare solution speed of kinds of Ermiao Pellets in vitro. The result indicates that solution speed of ultra powder is quicker than of general powder, and whit granularity decreasing the speed increases. So the technology of Chinese herbs ultra grind can be applied in preparation for Chinese herbs pellets and micropellet, which provides a certain basis for innovation of forms of drugs.In order to study the effect of the technology of superfine on toxicity of deadly poisoned Chinese herbs, acute toxicity tests of general and ultra powder Strychnos Nux-vomica power are studied and compared. LD50 of general powder and ultra powder were calculated by modified Kou's method, are respectively 223.95mg/kg, 198.05mg/kg.Apparent pharmacokinetics parameters of oral general powder and ultra powder are measured by drug's accumulated method. The results indicate these two kinds of powders both conform to one compartment open model. Tmax are...