Experimental Research On Biocompatibility Of The Novel PLA-PVP Amphiphilic Copolymers And Osteogenic Abilities By Combing Recombinant Human Bone Morphogenetic Protein-2

[Object]: To observe the material incorporation with the jaw bone and the reconstruction of the jaw defects by using the polylactic acids, the novel PLA-PVP amphiphilic copolymers and PLA-PVP / rhBMP-2 compounds to repair the jaw defect in order to study the histocompatibility and biodegradation of the novel PLA-PVP amphiphilic copolymers and assess the properties of the novel PLA-PVP amphiphilic copolymers as a biodegradable scaffold material by preparation of PLA-PVP / rhBMP-2 compounds, physical examination and animal experiment.[Methods]: Twenty-four healthy adult New Zealand white rabbits were divided into three groups randomly, 8 in each group. The penetrating 15 ×6mm defect was made by dental drill at the inferior border of mandible in each. The polylactic acids was implanted in group A, the novel PLA-PVP amphiphilic copolymers and PLA-PVP / rhBMP-2 compounds were used in group B and C. The rabbits were killed at 2, 4, 8, 12 weeks after implanting to make observation by using anatomy, X-ray, histology, Dual Energy X-ray Absorptiometry(DXA), Scanning Electron Microscope (SEM). Besides, the rabbits were detected by Isotope Bone Imaging at 4 and 8 weeks after implanting.[Results]: Every group were hardly rejected by the hosts, participating in new bone formation. The bone density of each group gradually increased with time and with significant differences in 2^nd, 4^th ,8^th and 12^th week (P<0.001) . The bone density had significant difference between groups C and B as well as groups B and A. X ray indicated that the bony callus density of each group gradually increased with time and there was significant difference between every group. Evidences from histology and Scanning Electron Microscope showed that the materials of each group were degraded step by step while new bone gradually substituted for the materials and repaired the...