The Investigation Of The Plasma D-dimer Lever In Different Type Of Coronary Heart Disease

Objective: To evaluate the plasma D-dimer and fibrinogen level in the different varieties of coronary heart disease and investigate their correlation. Method: 71 subjects were divided into four groups according to clinical mani festation: ①acute myocardial infarction (AMI) group: 19 subjects; ②unstable angina pectoris(UAP)group: 20 subjects; ③ stable angina pectoris(SAP) group: 13 subjects; ④normal co ntrol group: 19 subjects. We also divide groups in the light of the results of coronary angiography as: ①complex lesion group: 39 subjects; ②simple lesion group: 13 subjects; ③negative control group: 19 subjects. Plasma D-dimer and fibrinogen level was measured and compared between different groups. The results were show as x|- ± s, and we use Mann-Whitney Test for comparing(SPSS13.0). Results: D-dimer: plasma concentrations were higher in AMI (197.16±107.79ug/L) and UAP (153.80±63.24ug/L) cases than those in normal control cases (69.84±33.92ug/L) (P<0.01); in SAP (114.31±51.83ug/L)also higher than controls (P<0.05); and between AMI and SAP cases, the plasma concentrations of D-D had obvious difference(P<0.05), but there was no difference between UAP, AMI and UAP, SAP cases(P>0.05). The plasma concentrations of D-D in complex lesion group (171.00±93.09ug/L) and simple lesion group (126.08±54.02ug/L) were higher than in negative control group (69.84±33.92ug/L) (P<0.01),but there was no difference between complex and simple cases themselves(P>0. 05).Fibrinogen: plasma concentrations were higher in AMI(3.52±1.07g/L) and UAP (3.07±0.46g/L) cases than those in normal control cases (2.43±0.40g/L) (P<0.01); in SAP (2.73±0.35g/L) cases, they also higher than controls(P<0.05); and in AMI or UAP cases the fibrinogen concentrations were higher than those in the SAPcases(P<0.05); The plasma concentrations of fibrinogen in complex lesion group (3.22±0.87g/L) and simple lesion group (2.92±0.35g/L) were higher than in negative control group (2.43±0.40g/L) (P<0.01), but there was no difference between complex and simple cases. Conclusion: The plasma levels of D-dimer and fibrinogen were related to the coronary heart disease, and had difference in different varieties, they had important value in forecast and diagnosis. But whether they related to the severity had not been determined.