Correlation Between D-dimer, Fibrinogen And Coronary Artery Disease

BACKGROUD: With the continuous improvement of living standards, the incidence of coronary heart disease (coronary heart disease, CHD) increased rapidly. Coronary heart disease (CHD) is caused by myocardial chemia and hypoxia because of coronary obstruction contributed by atherosclerosis.CHD is the first cause of death from heart disease. The mechanism of coronary heart disease is complex, Currently study shows a number of factors that may act on different aspects of the results. As arterial endothelial cell is damaged, the platelets adhere in the injured area, aggre -gate, activate the process of clotting, and induce monocyte - macrophage accumulating in the endothelium, then swallow a lot of lipids that result in the formation of lipid core; when athero -sclerotic plaque rupture, platelets are adhesive and aggregating, coagulation factors are activated, fibrinogen change into fibrin to form clots that block the circulation of coronary or even form coronary thrombosis, which lead to acute myocardial infarction.. The incidence of coronary heart disease and development process have been invouled by a variety of platelets and coagulation factors, so endothelial cell injury and an imbalance in coagulation and fibrinolysis during coronary heart disease have cause people's high attention. For reason of extra injury by coronary angiography, the researchers pay more attention to related indicators to predict coronary artery disease .And D-dimer (DD), fibrinogen (Fbg) become the focus of attention and reports about the correlation between D-dimer (DD) and fibrinogen (Fbg) .OBJECTIVE: To investigate the relavence of D-dimer, fibrinogen and coronary artery .METHODS: 92 patients with CHD were selected, of which 28 patients with stable angina, 34 patients with unstable angina (UA) patients, 30 patients with acute myocardial infarction (AMI) and 30 patients normal controls. DD and Fbg in each group were measured, and coronary heart disease based on results of coronary angiography group was divided into single-vessel disease in 36 patients, 29 patients with two lesions narrow, three lesions narrow in 27 cases for the comparison of DD and Fbg respectively.RESULTS: AMI, UA group DD, Fbg were significantly higher than SA group (P <0. 01); AMI group was significantly higher than that of UA group (P <0.05). FG had no significant difference between AMI group and the UA group (P> 0.05). Coronary of two, three lesions narrow groups FG and DD level was higher than normal control and a disease group, the difference was significant (P <0.01), three lesions narrow were higher than two lesions (P <0.05), One lesion narrow group and control group had no significant difference between groups (P> 0.05).CONCLUSION: By case analysis of stable angina, UA, AMI and normal patients , we found that DD , Fbg as the indicators of the coronary events their degrees are correalation with stenosis of coronary angiography, that shows the increase of Fbg and DD are highly related to coronary artery disease and they can be a prediction of coronary artery disease and an important reference to determine the value and clinical significance.