A Study On The Relationship Between Resistin And Complement Regulatory Protein CD55,CD59 In Hyperlipidemia

Objective To study the expressions and relationship between serum resistin and Complement regulatory protein CD55s CD59 in patients with hyperlipidemia.Methods We selected 50 patients with hyperlipidemia ,and 21 healthy people matched in terms of age , sex , and body weight as control. The serum resistin concentration was measured by using ELISA. The expression of CD55,CD59 on white blood cells were detected by flow cytometry.Results We found the serum resistin levels were higher in patients withhyperlipidemia than in controls(P < 0.05). Futhermore we found the serum resistin levels had significant positive correlation with total cholesterol (r=0.297, P<0.05) but no correlation with BMI, waist-hip ratio and blood glucose. Femaleshad higher resistin levels than males(P< 0.05).The mean fluorescence intensity ( MFI) and the percentage of CD55 positive lymphocyte were decreased in patients with hyperlipidemia compared with control (P<0.05). The percentage of CD59 positive granulocytes were decreased in patients with hyperlipidemia compared with control (P<0.05). CD55 positive lymphocyte MFI was negativecorrelated with BMI (r=-0.238, P=0.045) , waist circumference (r=-0.253, P=0.033) , waist-hip ratio(r=-0.325, P=0.006). The percentage of CD55 positive monocytes was negative correlated with BMI (r=-0.361, P=0.002) , waistcircumference(r=-0.338, P=0.004), waist-hip ratio(r= -0.301, P =0.011). Multipleregression analysis indicated that waist-hip ratio was significant predictor of CD55 positive lymphocyte MFI and the waist circumference was significant predictor of the percentage of CD55 positive monocytes. The serum resistin levels were not correlate with the MFI and the percentage of CD55,CD59 positive cells.Conclusion The serum resistin levels were higher in patients with hyperlipidemia than in controls and the serum resistin levels had significant positive correlation with total cholesterol. Females had higher resistin levels than males. The expression of Complement regulatory protein were decreased in patients with hyperlipidemia compared with control and were negative correlated with waist circumference, waist-hip ratio. That indicated obesity, especially central obesity may influence the expression of complement regulatory protein. The serum resistin levels were not correlate with the MFI and the percentage of CD55,CD59 positive cells. Whether other adipokines can influence the expression of complement regulatory protein need to further study.