Flurbiprofen Ester Perioperative Use Of The Feasibility Study

Objective : To study the effect of flurbiprofen in perioperative Bank ofpreemptive analgesia efficacy and safety of the clinical studyMethods : choose ASA I - II, age 55nm-year-old middle elective surgery undergeneral anesthesia were 60 cases studied, 30 were males and 30 female cases 50～75kg weight, all patients were using intravenous rapid intubation after induction of TIVA, induction of anesthesia with midazolam 0.1mg.kg-1, fentanyl 2～4ug.kg-1. 1～2mg.kg-1 propofol and vecuronium 0.1mg.kg-1. Tracheal intubation after connecting narcotic control breathing. Maintenance of anesthesia use of propofol and remifentanil continuous intravenous infusion, surgery on Demand intermittent intravenous Vecuronium maintain anesthesia. The patients were monitored during surgery HR, ECG, and SPO2 PatCO2. Records bleeding. After the operation tube extraction, to be completely clear after patients into wards.According to the use of analgesic drugs randomly divided into two groups, group I flurbiprofen ester trip preemptive analgesia, 30 minutes before induction of anesthesia injection flurbiprofen ester (Kay disputes) lmg.Kg-1 (diluted with saline to 10 ml), group II patients to slow in 10ml saline injection. 30 patients in each group, which continued for the detection of patients blood pressure (BP), mean arterial pressure (MAP) and heart rate (HR), Electrocardiogram (ECG), pulse oxygen saturation (SpO2). In 30 minutes before anesthesia (T1, not to flurbiprofen in Ester and placebo), 6 h after surgery (T2), after 24 hours (T3), the patients were taken as a 2 ml blood sample, Determination of platelet CD62P expression. Using visual analogue scale (VAS) for postoperative analgesic effect of postoperative nausea and records, adverse reactions such as vomiting and postoperative analgesic drug use. All data were used SPSS 10.0 software, the P "0.05 for the difference was statistically significantResults:1,General information : two patients age, weight, sex and ASA, the difference wasnot statistically significant2,Comparison of surgery : anesthesia induction time, duration of anesthesia, surgicaltime, intraoperative fluid, blood loss, Intraoperative urine and intraoperative use ofnarcotic drugs, the difference was not statistically significant (P> 0.05)3,Analgesic effect of comparison : the time points after the VAS score, and thedifference was statistically significant (P < 0.05)4,Respiratory and circulatory changes(1)MAP comparison : after the point of comparison with T1, the difference was notstatistically significant (P> 0.05)(2)HR comparison : after the same point in group I and group II, the difference wasnot statistically significant (P> 0.05)(3)SpO2, RR changes : two points the same time, after the de facto compared with T1,There was no significant difference (P> 0.05)5,Adverse reactions : group I, no nausea, vomiting, and other adverse reactions,Section II A, the comparison between the two groups. There was no significantdifference (P> 0.05)6,Each group of three de facto expression of platelet CD62P significant differences,after CD62P expression was significantly higher than that before. Two groups ofpatients should be de facto relative expression of platelet CD62P no significant difference (P> 0.05).7,Patients in both groups a 24-hour analgesic drug needs are different, group IIpatients ampules demand significantly more than group 1.Conclusions:1,Flurbiprofen ester preemptive analgesia trip to the enhancement of good patientwithin 24 hours of the analgesic effect the patient vital signs stable2,Flurbiprofen ester for perioperative preemptive analgesia is safe, effective andfeasible.3,Flurbiprofen ester application not significantly affect platelet aggregation activationof the coagulation system no significant impact safe for perioperative.