Study Of The Relationship Between Obstructive Sleep Apnea Syndrome And Obesity, Serum Resistin Concentration

Objective To Investigate the serum resistin concentration in healthy volunteers and patients with obstructive sleep apnea syndrome (OSAS), and study the relationship between OSAS and obesity, serum resistin concentration.Methods Precisely measured all bodys' height and weight, calculated body mass index (BMI). According to the body mass index (BMI), 35 OSAS patients were divided into two groups: One group was normal weight patients (BMI: 18. 5—24. 9kg/m2, 14 cases) and the other group was overweight patients (BMI≧25 kg/m~2, 21cases). There were 40 healthy volunteers in control group. Detected the systolic blood pressure (SBP) and diastolic blood pressure (DBP), fasting levels of plasma glucose (FPG), total cholesterol (TC) and triglyceride (TG), and tested resistin concentration in plasma. Examined and recorded the apnea-hypopnea index (AHI), the average oxygen saturation and the minimum oxygen saturation in 35 OSAS patients with Polysomnography.Results①The serum resistin concentration of OSAS overweight group were higher than OSAS normal weight group, and the later were higher than control group. The distinction of serum resistin concentration between OSAS overweight group and control group was significant (p<0.05).②In OSAS overweight group, The indexes of BMI, SBP, DBP and AHI were notably higher than those for OSAS normal weight group (p<0.01), and the BMI, TG, SBP, DBP were higher than those for control group (p<0.05).③In OSAS patients, BMI was positively correlated with AHI and SBP, and negatively correlated with the average oxygen saturation and the minimum oxygen saturation.④Serum resistin concentration was positively correlated with TG, FPG and DBP. Multiple stepwise regression analysis revealed that serum resistin concentration was associated with TG and FPG. (p<0.05)Conclusions The serum resistin concentration is enhanced in OSAS patients and trend to ascent with obesity aggravating. OSAS patients accompany with the disorder of blood pressure and serum lipid. Obesity or abdomen obesity may aggravate the hypoxia in OSAS patients. Serum resistin concentration was positively correlated with TG, FPG and DBP. TG and FPG are important factors in serum resistin concentration, which indicate that in OSAS patients, the lipid metabolism, glycometablism and resistin would interact on each other.