Clinical Studies Of Ligustrazine Phosphate And Glucose Injection On Accelerating The Growing Of Granulation Of The Acute Wound Treated By The Vacuum Assisted Closure

Objective: The aim of the study was to assess the effect of the drug for promoting blood circulation- Ligustrazine Phosphate and Glucose Injection on the acute wound treating by Vacuum-assisted Closure, and to confer the mechanism of them through observing the growing of granulation of the skin wound and the time to do the stageⅡoperation to close the wound.Methods: 43 patients from July, 2006 to March, 2007 treating by Vacuum-assisted Closure were randomly assigned to the treating group or to the control group. Thetreating group was treated by Vacuum-assisted Closure combined with Ligustrazine Phosphate and Glucose Injection, and thee control group was treated only by Vacuum-assisted Closure. The course was ended when removing Vacuum-assisted Closure. growing of granulation of the skin wound and the time to do the stageⅡoperation to close the wound of two groups were observed and compared.Results:1. The index of growing of granulation of the skin wound when removing the Vacuum-assisted Closure for the first time and the time to do the stageⅡoperation to close the wound of treating group and control group has significant difference (P＞0.05). It shows that management of treating group could improve the the growing of granulation of the skin wound and shorten the time to do the stageⅡoperation to close the wound. The index of growing of granulation of the skin wound when removing the Vacuum-assisted Closure at last of two groups have no significant difference(P＞0.05) which showed the granulation grew well by the management of the Vacuum-assisted Closure.2. Arbe, index K of treating group have significant difference (P＜0.05) after operation compared with pre-treatment. Arbe, index K of the treating group have significant difference (P＜0.05) after operation compared with the control group. Hemorheology of control group have no significant difference (P＞0.05) whether before or after. It showed the management of the treating group was better than the control group in reducing the high coefficient of viscosity after operation..3. The cure rate of treating group and control group have no significant difference (P＞0.05) that showed Most of acute wound can close the wound by stageⅡoperation. Most of them can close the wound by stageⅡoperation.4. Both of the two groups have no significant difference in routine blood test, routine urine test, routine stool test, heart function, liver function, kidney function during the study comparing with the pre-treatment. There is no allergic reaction and adverse drug reactions during the treating.Conclusion:1. Ligustrazine Phosphate and Glucose Injection can improve the growing of granulation of the wound and shorten the time to do the stageⅡoperation to close the wound, shorten the days to be hospitalized and reduce the cost.2. Ligustrazine Phosphate and Glucose Injection can reducing the high coefficient of viscosity after operation and improve hemorheology of the acute wound.3. Granulation of the acute skin wound grew well when treating by the Vacuum-assisted Closure. Most of them can close the wound by stageⅡoperation.4. Both of the two groups have no difference on safty index. Ligustrazine Phosphate and Glucose Injection is safe and feasible onthe the acute wound treating by Vacuum-assisted Closure.