The Clinic Research Of The Effect Of Yiqi Huoxue Fa Reversing Blood Endothelium Function Obstacle In Coronary Angina Pectoris

Objective: To validate clinicalcurative effect that Buyang Huanwu Decoction improveclinical symptom and prognosis in patients of coronary heart disease through testingthe level of ET-1, NO, vWF in serum and FMD.Method: This is a single-blind, randomized, matched controlled trial. 60 patients thatwere diagnosed as coronary angina pectoris and qixu xueyu symdrome wererandomly grouped to treatment group and controlled group. Each group had 30 cases.The two groups were treated with Buyang Huanwu Decoction and placebo separatelyon the basis of basical treatment by 3 weeks continuously. After 3 weeks, we observedthe change of ET-1, NO, vWF, FMD, EKG reading, clinical symptoms of anginapectoris, and Chinese medical symptoms.Result:Clinical symptoms of angina curative effect: Symptoms of angina were improvedeffectively in treatment group, while there was no statistical significance in controlledgroup. Treatment group shown 90ï¼…and controlled group shown 66.7ï¼…. Theirdifferences had great statistical significance.EKG curative effect: The EKG curative effect of the two group separately shown86.7ï¼…and 56.7ï¼…. Their differences had great statistical significance.Chinese medical symptoms curative effect: Chinese medical symptoms wereimproved effectively in two groups, but the treatment group was more improved thancontrolled group. Treatment group shown 90ï¼…and controlled group shown 66.7ï¼….Their differences had great statistical significance.ET, NO: Although the level of ET in serum decreased and the level of NO increased in controlled group, there were no statistical significance. The level of ET decreased,the level of NO increased after treatment in treatment group which had greatstatistical significance. The level of ET in serum was much lower than that ofcontrolled group after treatment. The level of NO in serum was much higher than thatof controlled group after treatment.vWF: The level of vWF of treatment group was lower than controlled group whichhad statistic significance. Furthermore, the level of vWF was much lower than that ofcontrolled group after treatment. Although the level of vWF of controlled groupdecreased but there was no statistical significance.FMD: There was no change of FMD in two groups after treatment. There was nochange of FMD alter treatment in the same group.Conclusion: The results of the experiment show that Buyang Huanwu Decoction caneffectively improve EKG curative effect. It can control angina pectoris attack,improve Chinese medical symptoms without side-effect. By decreasing the level ofET and increasing the level of NO in serum and controlling reversed bloodendothelium function obstacle partly.