The Plasma HGF Level In Patients With Non-Hodgkin Lymphoma And Its Clinical Significance

Objeetive:Angiogenesis is associated with growth and metastasis ofcancer, which confirmed in solid tumor and certain hematological diseasessuch as non-Hodgkin lymphoma. Hepatocyte growth factor(HGF) is amultifunctional cytokine that can stimulate the movement of tumor cellsand angiogenesis. Many studies discover the concentration of the bodyfluid HGF in patients with breast carcinoma, non-small cell lung cancerand gastric cancer increase, which associated with tumor invasion, and itcan be one of the prognostic factor. There are also some similar studies inmalignant hematological diseases. In this study ELISA is used to detect theplasma HGF level in NHL patients at different stage, in order to investigatethe association between plasma HGF and clinical characters in NHLpatients. It is hope to study NHL from angiogenesis so as to have a newstrategy for the treatment of NHL patients and to observe the clinicalcondition in NHL patients.Methods:We measured the plasma HGF in NHL patients by ELISA;collect clinical materials and analyze the data with SPSS.Results:P-HGF levels in NHL patients were significantly higher thanthose in healthy controls(P＜0.01). P-HGF levels in newly diagnosed andrelapsed NHL patients were higher than those in complete and partialremession ones(both P＜0.05), but no difference was found between newly diagnosed patients and relapsed ones(P=0.672). Change of P-HGF levels innewly diagnosed patients were not associated with treatmentreponse. There were no difference about P-HGF levels in newly diagnosedand relapsed patients with different gender, age, immunological type, Bsymptoms and number of extranodal site involved (P: 0.172, 0.496, 0.123,0.834, 0.506). But P-HGF levels in NHL patients with advanced Ann Arborstage (P=0.032), media and high aggression (P=0.025), high IPI scores(P=0.047) were significantly higher. Compared with those with normalLDH levels, P-HGF levels in NHL patients with higher LDH were elevated(P＜0.05), P-HGF levels were positive correlated with LDH levels (r=0.36,p＜0.05). Compared with those with normalβ2-MG, P-HGF levels in NHLpatients with higherβ2-MG were elevated (P＜0.05), P-HGF levels werepositive correlated withβ2-MG levels (r=0.129, P＜0.05). P-HGF levels innewly diagnosed and relapsed patients were positive associated withmonocytes (r=0.492, P＜0.01) but not with WBC, Hb and Pt(P＞0.05).Conclusion: P-HGF of NHL patients was higher than that of healthyadults. P-HGF levels were associated with malignant grade, advanced AnnArbor stage and high IPI scores, it also positive correlated with LDH,β₂-MG and monocytes. HGF perhaps involved in the development ofNHL, and monocytes may produce HGF. P-HGF might be used to monitordisease status and have a pognotic value in NHL patients.