The Relationship Between Recurrent Cerebral Infarction And Serum Folic Acid As Well As Serum Vitamin B₁₂

Objective To study the relationship between recurrent cerebralinfarction (CI) and concentration of serum folic acid (FA) and vitamin B₁₂(VitB₁₂), and compare the effect of FA with VitB₁₂ on recurrent CI.Methods The concentrations of serum FA and VitB₁₂ in 166patients with acute CI were measured in the 1st and 7st day after theirbeing in hospital, their average value were calculated. In the 7st dayafter their being in hospital, it is detected if there were hypertension,diabetes, hyperlipidemia, coronary heart disease in 166 patient with acuteCI. 166 patients with acute CI were divided into two groups: group withnormal FA and VitB₁₂ concentration and group with FA and VitB₁₂concentration decrease; group with FA and VitB₁₂ concentration decreasewas randomly divided into groups with or without FA and VitB₁₂treatment. All groups were given same supportive treatments and werefollowed up 2 years. All patients were recorded if there were recurrent CI.Patients without FA and VitB₁₂ treatment were again divided intoinitialized CI group and recurrent CI. The concentration of FA and VitB₁₂was compared; CI recurrent rate was compared between group with FAconcentration decrease and normal group, group with VitB₁₂concentration decrease and normal group, group with FA and VitB₁₂concentration decrease and normal group; CI recurrent rate was comparedbetween group with FA concentration decrease, group with VitB₁₂concentration decrease, group with FA and VitB₁₂ concentration decreasewith or without treatment. Results After 2 years, 160 patients have been followed up,including 42 patients with FA and VitB₁₂ treatment and 118 patientswithout FA and VitB₁₂ treatment. 6 patients lost follow up including 4patients with normal FA and VitB₁₂ concentration and 2 patients with FAand VitB₁₂ concentration decrease.â‘ In 118 patients without FA andVitB₁₂ treatment, the concentration of serum folic acid(FA:3.613±1.820μg/L) and vitamin B₁₂ (VitB₁₂:368.13±180.57 ng/L) ofthe recurrent CI group (30 patients) is evidently lower than that of theinitialized CI group (88 patients, FA: 5.645±1.713μg/L, VitB₁₂:512.84±161.93 ng/L) (p＜0.01).â‘¡In 118 patients without FA and VitB₁₂treatment, CI recurrent rate of group with FA concentration decrease(53.33%) is evidently higher than that of normal group (15.91%)(p＜0.01); CI recurrent rate of group with VitB₁₂ concentration decrease(50.00%) is evidently higher than normal group (14.63%) (p＜0.01); CIrecurrent rate of group with FA and VitB₁₂ concentration decrease(46.15%) is evidently higher than that of normal group (10.26%)(p＜0.01).â‘¢In group with FA concentration decrease, CI recurrentrate of group with FA treatment (40.00%) is lower than that of groupwithout FA treatment (53.33%), but there is no difference between twogroups (p＞0.05); In group with VitB₁₂ concentration decrease, CIrecurrent rate of group with VitB₁₂ treatment (36.84%) is lower than thatof group without VitB₁₂ treatment (50.00%), but there is no differencebetween two groups (p＞0.05); In group with FA and VitB₁₂ concentrationdecrease, CI recurrent rate of group with FA and VitB₁₂ treatment (30.77%) is lower than that of group without FA and VitB₁₂ treatment(46.15%), but there is no difference between two groups (p＞0.05).Conclution The concentration decrease of FA and VitB₁₂ may be adangerous factor to induce CI recurrence; oral FA and VitB₁₂ treatmentdon't reduce CI recurrence.