| Objective:Vascular dementia is a type of dementia，its incidence is second toAlzheimer’s disease， It’s due to cerebrovascular disease caused bycognitive impairment, and acquired a syndrome of intelligent damaged, Ithas a strong impact on quality of life of elderly patients. There are manyfactors affecting the disease, among them, the more discussion is plasmahomocysteine, folic acid, vitamin B12level by foreign scholars. Studieshave confirmed that homocysteine in AD, development played a crucialimpact. But its effect on the occurrence of vascular dementia anddementia degree reported less, the reports and research at home andabroad have different conclusions.To investigate the correlation betweenplasma homocysteine, folic acid, vitamin B12level, cerebral infarctionand vascular dementia.To offer a new way for prevention and treatmentof vascular dementia. And according to the scale of filtered light andheavy, moderate vascular dementia patients into light and heavy,moderate three groups, using analysis of variance (F test),Methods:This study select68cases of the hospitalized patients with is chemiccerebrovescular disease, who are from the neurology ward of JilinUniversity China-Japanese union hospital, China-Japanese union hospitaldepartment, China-Japanese union hospital in south lake campus department from March2011to October2013. Meanwhile, the researcherselect20cases of medical healthy elderly patients with in the same periodrandomly as a healthy control group (except for other diseases,enrolledpatients do not have marked differences in age and sex).Hospitalized patients were diagnosed within24-72hours receivingCT and MRI scan and other related auxiliary examination after beingadmitted to hospital. According to MoCA scale, Hachinski IschemicScale, the selected patients were divided into32cases with vasculardementia and36cases with non-infarct dementia group. All these patientswere measured about the plasma Hcy, folic acid and vitamin B12levelwith taking2~3ml fasting blood sample of elbow. The researcher usesSPSS17.0statistical software for statistical analysis. Among them,categorical data descriptive analysis with X±S, Using logisticregression analysis of HCY, vitamin B12, folic acid effects on dementia.To compare correlation between homocysteine, folic acid, vitamin B12and dementia degree.Results:The plasma Hcy level in VD patients group and cerebral infarctiongroup is higher than normal control group, P＜0.05,the difference issignificant, meanwhile, folic acid and vitamin B12level in VD patientsgroup and cerebral infarction group is lower than normal control groupobviously, P＜0.05,the difference is significant. Moreover, the plasma Hcy level in VD patients group is higher than cerebral infarction group, P＜0.05,the difference is significant, and folic acid and vitamin B12levelin VD patients group is lower than cerebral infarction group, P＜0.05,thedifference is significant.Depending on pairwise comparison analysis withBonferroni method and the results of univariate analysis, the researcherputs the significant factors into binary logistic regression analysis. Theresults show the risk of vascular dementia will increase4.758times ifHcy level increases1pmo l/L. When the level of Vitamin B12and Folicacid increases1pmol/L, the risk of vascular dementia will decrease0.544times and0.062times. There are no significant differences in levelof Hcy, vitamin B12and folate between different level of VD group.Conclusion:1. Hcy level of vascular dementia group is significantly higher than non-infarct dementia group and healthy control group.2. Folic acid and vitamin B12level of vascular dementia group issignificantly lower than non-infarct dementia group and healthycontrol group.3. Hcy is a risk factor of cerebral infarction and vascular dementia. Thefolic acid and vitamin B12are protective factors of vasculardementia.4. Hcy level dosen’t affect in the degree of dementia. |
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