The Level And Its Significance Of Serum ADPN In The Patients Of Breast Cancer

Objective:To explore the role of Adiponectin(ADPN)in the development of breast cancer by analyzing the change of level in the patients of breast cancer and the relationship between the serum adiponectin levels and the various clinicopathological characteristics of breast cancers.Methods:Serum adiponectin levels were measured by ELISA in 64 cases patients of breast cancer and 35 cases healthy women.The relationship between serum adiponectin level and various clinicopathological characteristics of breast cancer including age,tumor size,ER,PR, menopause status,pathological grade,and lymph node metastasis was examined.Results:Compared with the healthy women,serum adiponectin level of patients were significantly lower(6.098±1.460 VS 8.691±1.883,P＜0.01).Such an association was observed both in the premenopausal women and in the postmenopausal women.The frequency of large(＞2 cm)tumors and that of high histological grade(Ⅱ+Ⅲ)tumors were significantly higher in breast cancer patients in the low serum adiponectin levels than those in the high levels.Conclusion:The breast cancer patients have a lower-circulating adiponectin levels independent of age,menopause status,BMI,hormone receptor status.Tumors arising in women with the low serum adiponectin levels are more likely to show a biologically aggressive phenotype.The ADPN may play a important role in the development of breast cancer.Our study indicates that adiponectin measurements may serve as a useful screening tool for predicting risk and for early detection of breast cancer and adiponectin or adiponectin analogues may prove to be effective anticancer agents and may have important therapeutic implications.