1. Differing Adminstration Time-Dependent Effects Of Aspirin On Blood Pressure In Hypertensive Patients 2. The Correlative Research Between Nitric Oxide And Essential Hypertension

Objective:The prupose of this research was to investigate in mild hypertensive patients the effects on NO and ambulatory blood pressure(ABPM)of aspirin(ASA)administered at different times of the day.Methods:We studied 55 untreated patients with grade 1 hypertension,47.90±13.19years of age,randomly divided into three groups:nonpharmacological hygienic-dietary recommendations,the same recommendations and ASA(100mg/day)on awakening,or the same recommendations and ASA before bedtime.ABPM and blood serum NO was measured before and after one month of intervention.Results:(1)Serum NO was significant elevated after aspirin on bedtime(P＜0.01),but no significant change after nonpharmacological and aspirin on awakening intervention(P＞0.05).(2) 24-hour systolic blood pressure(sbp)and diastolic blood pressure(dbp),daytime sbp and dbp, nithttime sbp and dbp were significantly reduced in the patients who received aspirin befor bedtime(P＜0.01),but no significant change after nonpharmacological and aspirin on awakening intervention(P＞0.05).Conclusion:The trial also documented a significant administration time-dependent effect of low-dose ASA on BP and blood serum NO in mild hypertensive patients.The timed administration of low-dose ASA coule provide a valuable approach,beyond the secondary prevention of cardiovascular disease,in the added BP control of patients with mild essential hypertension. Objective:The prupose of this research was to compare serum nitnic oxide(NO)of mild essential hypertension(EH)and normal hypertension,dipper and non-dipper hyperstensive.Methods:Fifty-five patients with grade 1 EH and forty-two normal individuals were selected to measure their weight and other routine test,as well as the serum NO.EH subiects were measured by ambulatory blood pressure(ABPM),and then subcalssified according to the percentage of nocturnal SBP reduction as follows:dipper if the nocturnal SBP reduction was≥10%;nondipper if the fall was＜10%.Results:(1)Serum NO levels in patients with EH(56.96±11.86μmol/L)were significantly lower than that in normal controls(74.73±10.47μmol/L)(P＜0.001).(2)EH Subjects were also subclassified as:dippers(n=26),non-dippers(n=29).(3)Nighttime systolic blood pressure(sbp) (123.51±9.40mmHg)and diastolic blood pressure(dbp)(77.96±8.59mmHg)in non-dipper hypertensives group were extremely higher than dipper hypertensives(individually were 110.88±9.43/69.96±8.09 mmHg)(P＜0.001).(4)In our study,serum NO are extremely decreased in non-dipper hypertensives group(49.75±10.43μmol/L)compared with dipper hypertensives(65.01±7.37μmol/L)(P＜0.001).Conclusions:NO is probably involved in the pathophysiological process of EH and in the disappearance of the circadian rhythm.