The Relationship Between Cardiovascular Disease Risk Factors And White Blood Cell Count

Objectives: The incidence and mortality rate of cardiovascular disease are increasing nowadays, give our country a heaven economic burden. But the basic reason of the cardiovascular disease is atherosclerosis. The reason what cause atherosclerosis is so much. In recent years, more and more researchers have thought that inflammation and the activation of many immunologic cells make an essential effect during the occurrence and development of atherosclerosis. The are many inflammation index and biochemical markers to monitoring the development of atherosclerosis, including CRP,half cystine,uric acid,fibrin etc, but these detection can not be generally developed in clinic. But the white blood cell count used quite normal in clinic. Recently, there are so much research between the white blood cell count and the coronary atherosclerosis disease. In our investigation we analysis 3006 civil servant's health examination data which including the white blood cell count,neutrality cell count and monocyte cell count to analysis the relationship between the white blood cell count and the cardiovascular disease .Methods: All the target people fast before the first day of get blood at 8 clock in the night. (including snacks, can drink a sprinkle water ),adopt sitting position venous blood the next day during 8~10 clock in the morning .Get 2ml venous blood add to EDTA anticoagulant's blood vessel, to detect the white blood cell count,neutrophile cell count and monocyte cell count in the blood. 2ml venous blood add to promote to freeze blood vessel, demesh blood serum to detect TC,TG,LDL,HDL and fasting blood glucose. The detection of blood glucose and blood fat use our hospital biochemical chamber's multifunction biochemistry detection meter. The detection of the blood routine uses the blood analyzer. The detection of the blood pressure use ohm complete automatic blood pressure measurement.Results:1. In the single factors'analysis of the white blood cell count and cardiovascular risk factors, high blood pressure,smoking,high TG,overweight and above middle-age's white blood cell count,neutrophil cell count and monocyte cell count have significant increase(P<0.0001). The white blood cell count and neutrality cell count of people with diabetes or advanced fasting blood glucose have significant increase(P<0.0001), the monocyte cell count also have a significant increase (P<0.01). Compared people whose LDL≥4.1 mmol/ L and LDL<4.1 mmol/ L, the white blood cell count have a significant increase(P<0.05), monocyte count has a significance increase(P<0.01), neutrophil count has no significant difference(P>0.05). Compared people whose HDL-C<1.04 mmol/ L and HDL-C ≥1.04 mmol/ L, the white blood cell count have a significant increase(P<0.05), monocyte count has a significance increase(P<0.0001), neutrophil count has no significant difference(P>0.05). Compared people whose TC≥6.3mmol/ L and TC<6.3mmol/ L, the white blood cell count have a significant increase(P<0.01), monocyte count has a significance increase(P<0.0001), neutrophil count has no significant difference(P>0.05).2. In the analysis of the white blood cell count and the concentrate mult-risk factors of cardiovascular disease, according to the number of the frequent 6 cardiovascular disease risk factors (high blood pressure,smoking,obesity,hyperglycaemia,LDL≥4.1mmol/ L,HDL-C<1.04 m mol/L) divided to 6 section. 795 people have 0 risk factor,977 people have 1 risk factor,813 people have 2 risk factors,350 people have 3 risk factors,66 people have 4 risk factors,5 people have 5 risk factors,0 people have 6 risk factors. With the increase number of risk factors, all of the section have increasing number of white blood cell count,neutrophil count and monocyte count.3. In the analysis of the white blood cell count and the metabolic syndrome, the metabolic syndrome suffer have increasing white blood cell count,neutrophil count and monocyte count(P<0.0001).4. In the analysis of the white blood cell count and the concentrate mult-risk factors of metabolic syndrome, according to the number of the risk factors of the metabolic syndrome divided to 5section. 145 people have 0 risk factor,524 people have 1 risk factor,694 people have 2 risk factors,870 people have 3 risk factors,773 people have 4 risk factors. With the increase number of risk factors, all of the section have increasing number of white blood cell count,neutrophil count and monocyte count.5. In the Logistic regression analysis of the white blood cell count,neutrophil count,monocyte count and the concentrate mult-risk factors of cardiovascular disease, the white blood cell count is the independence risk fact of age(OR 1.5,95% CI 1.32-1.83, P = 0.0001),high BMI (OR 1.24,95% CI 1.03-1.46, P = 0.047),high contractive blood pressure(OR = 1.26,95% CI 1.05-1.48, P = 0.03),high HDL-C(OR 3.18,95% CI 2.08-4.28, P = 0.04)and high TG(OR 1.95,95% CI 1.70-2.21, P = 0.0001). Neutrophil count is the independence risk factor of high diastolic blood pressure blood pressure(OR 1.40,95% CI 1.17-1.63, P = 0.004),high fasting blood glucose(OR 1.93,95% CI 1.68-2.19, P = 0.0001 ) .Monocyte count is the independence risk factor of age(OR 1.68,95% CI 1.43-1.94, P = 0.0001),high BMI(OR 1.62 ,95% CI 1.40-1.84, P = 0.0001),high contractive blood pressure(OR 1.68,95% CI 1.47-1.90, P = 0.0001),high diastolic blood pressure(OR 1.43,95% CI 1.19-1.66, P = 0.003),high LDL(OR 1.8,95% CI 1.50-2.10, P = 0.0001),high TC(OR 1.71,95% CI 1.46-1.96, P = 0.0001)and high TG(OR 1.53,95% CI 1.27-1.80, P = 0.002). Conclusions: In the official people, white blood count especially monocyte count and cardiovascular disease risk factors have intimate correlation. The relationship between it and the long-term prognosis of cardiovascular disease need further research.