Veratrine Antihypertensive Effect And Mechanism Of The Experimental Study

Veratrine antihypertensive effect and mechanism of the experimental studyObjective: By Veratrine the antihypertensive effect and mechanism of in-depth studies for the development of new medicinesâ…¡lay the theoretical foundation.Methods: Using direct pressure carotid tail artery and indirect pressure, duodenum and gavage to Veratrine. Determination of its normal cats, blood pressure in hypertensive rats and the impast of rapic tolerance. Veratrine vertebral artery and femoral vein administration administration comparec antihypertensive effect; Clipping or release the external carotid artery, Tongue to reverse arterial injection Veratrine, observation of the instantaneous rate of contraction of the membrane; through isolated perfused rabbit ears to observe the trial if there is any direct role in the dilation of blood vessels.Results: Veratrine normal cats systolic blood pressure, mean blood pressure, diastolic blood pressure were significantly reduced role at 10 min after administration with effective and sustainable ro e in more than 120 minutes, the heart rate is somewhat lower, But no significant statistical significance of the respiratory rate and respiratory rate of no significant impact. SHR of systolic blood pressure in spontaneously hypertensive rats significantly reduced role in drug 0.5h after onset, and sustainable over 2 hours, while in medicine 0.5h with a marked slowing heart rate role. After administration of cadmium right renal hypertensive rats were significantly lower blood pressure and reduce the role of HF, With its antihypertensive effect of increasing the dosage, and enhance. Antihypertensive repeated adm nistration does not have a clear role in the rapid tolerance. Through the mechanism of blood pressure blood pressure is not part of the central role that its non-central antihypertensive drug. No ganglior biocking role. 5-20 ml in the context of the isolated rabbit ears irrigation had no significant impact on traffic flow Veratrine that is not directly vasodilating effect. Blood pressure is the main mechanism in the carotic sinus and cardiopulmonary feelings, After sinus nerve and vagal afferent reflex inhibit vascular exereise centers, and decrease blood pressure.Conclusion: Veratridine on blood pressure was reduced, the heart rate is somewhat sower, its antihypertensive effect without rapid tolerance. Blood pressure is the main mechanism in the carotic sinus and cardiopulmonary feelings, After sinus nerve and vagal afferent reflex inhibit vascular exercise centers, and decrease blood pressure. Will veratridine into a new antihypertensive drug has good prospects, toxic medicine research deserves attention.