Studies On Nano-anti-infection Silicon Rubber Catheter Material

The aim of this paper is synthesizing a kind of nano-antiinfectionsilicon rubber catheter material, which owns the characteristic of finephysical mechanics and good antiinfection properties. What's more, suchmaterial can retain the effect of antiinfection for more than 20 days.Montmorillonite(MMT), which possesses good hydrophilicity, wassynthesized with quaternary ammonium salt (QAS) modification intoorganic montmorillonite (OMMT), a substance being hydrophobic andlarger in layer-distance. Meanwhile, a comparing study was done onmechanic stiring method and ultrosonic technology to get differentOMMT. X-ray diffraction (XRD) showed that the layer-distance ofOMMT through whole ultrosonic technology was 2.51nm while that bymechanic stiring method was only 2.27nm. Afterwards, OMMT was madewith QASs which had different chain length, followed by the result thatthe intercalating effect was not better though the chain length of QAS waslonger. Polarizing microscope indicated that the OMMT granule dispersedbetter after modification..A secondary intercalating modification was performed withAmikacin and Bardac(?)2280 based on OMMT to make Amikacin/MMTand Bardac(?)2280/MMT separately. The optimized synthesis technics ofcomposite materials was studied by morthogonal test. Consequently, theoptimized synthesis technics for Amikacin/MMT was as follows: reactiontemperature 60℃, ratio of casting stuff(m_Amikacin:m_OMMT) 1: 4, reaction time3h, PH 7.0; while that for Bardac(?)2280/MMT is 50℃, 1: 1, 4h and 4.0correspondingly. XRD showed that diffraction angle became smaller andlayer-distance got larger for these two kinds of composite materialsespecially for Bardac(?)2280/MMT. Polarizing microscope indicated thediameters for these granules minish and disperse even better, particularly for Bardac(?)2280/MMT. Bacteriostatis effect showed thatBardac(?)2280/OMMT had a better effect.Amikacin/OMMT rubber and Bardac(?)2280 catheters were preparedby intercalating compounding with a two-roll mixer. Afterwards, aserial of analysis was done on calorific, mechanical and antibacterialproperties. Differential scaning caloric (DSC) showed that siliconrubber could rime in a lower temperature, which made it could make intouse in such temperature; 7.5 percent was the best ratio forAmikacin/OMMT rubber and 7.5 percent for Bardac(?)2280 consideringmechanical property. The result showed that mechanical properties wereimproved as percentage of OMMT composites increased andBardac(?)2280 was more obvious than Amikacin/OMMT; meanwhile,Bardac(?)2280/OMMT dispersed better than Amikacin/OMMT inamong rubber; finally, drug releasing and antibacterial result showed thatAmikacin/OMM-rubber behaved well and Bardac(?)2280/OMMT-rubberwas much better therefore Bardac(?)2280 could be fully applied forsuch antibacterial catheters.