Construction Of Multifunctional Silicon-Based Nanocomposites And Their Applications For Anti-Bacterial Infection And Wound Healing

Bacterial infection and prolonged wound healing have been troubling clinical and real life,leading to damage to peoples' health and life.Therefore,it is of great significance to develop functional materials with good antibacterial and wound healing promoting activity.Because of their excellent stability,easy modifiability and benign biocompatibility,silicon-based nanomaterials have gained wide attention in the field of biomedicine.Combining silicon-based nanomaterials with natural bioactive compound(e.g.,notoginseng),this work aims to construct multifunctional silicon-based nanocomposite,which features excellent optical property,efficient antibacterial and hemostatic abilities,as well as significant wound healing promoting activity.The as-prepared silicon-based nanocomposite is loaded into chitosan to obtain a wound dressing with high anti-antibacterial performance,which is useful for rapid wound healing.The research strategies and contents of this paper are summarized as follows:Chapter one:we briefly introduce the development of nanomaterials for anti-bacterial infection and wound healing in recent years,then review representative progress of silicon-based nanomaterials in the field of biomedicine,and subsequently summarize the research status of silicon-based nanomaterials in the fields of bacterial detection,prevention and treatment of bacterial infection,as well as promotion of wound healing.On the basis of which,we present a discussion about the research background,basis and scheme of this paper.Chapter two:we select natural bioactive compound(notoginseng)and combine it with silicon nanomaterial to produce a kind of multifunctional silicon-based nanocomposite.The as-prepared silicon-based nanocomposite features strong and stable fluorescence(PLQY:?28%),good antibacterial property(about 82%resistance to S.aureus)and wound healing promoting activity(wound closure efficiency increased?10%).At the cellular level,we study the intracellular distribution of the silicon-based nanocomposite and demonstrate its inhibition of tumor cell growth.In vivo experiments further reveal that this type of silicon-based nanocomposite has combined effect of inhibiting S.aureus infection,hemostasis and promoting wound healing.Chapter three:we modify the silicon-based nanocomposite with peptide,and then load the modified material into chitosan membrane for constructing a kind of high-efficiency anti-bacterial membrane wound dressing.The dressing possesses excellent bending stress,good stability and benign blood compatibility(hemolysis ratio:3.52%).Meanwhile,the anti-bacterial membrane as a wound dressing features favorable water sensitivity,including hydrophilicity,water absorption property and permeability,suitable for absorbing inflammatory exudate and ensuring air permeability in the wound(water vapor permeability:2340.6 g·m-2·d-1).The membrane wound dressing also has excellent anti-bacterial property(inhibition zone against S.aureus:0.61 cm),which can effectively prevent bacterial infection and accelerate wound healing.Chapter four:we summarize the research work of the paper,discusse the innovation of this research and point out shortcomings of current studies.Then we put forward the prospect of the research work.To be summarized,in this paper,bioactive compound is combined with silicon-based nanomaterial to obtain composite functional silicon-based nanomaterials with excellent anti-bacterial/hemostatic/wound healing properties.The preliminary applications of the silicon-based nanomaterials are further realized for anti-bacterial infection and wound healing.This research holds potential scientific significance for the development of silicon-based nanomaterials in the field of wound care.