Plasma Neutrophil Elastase Concentration And Coronary Artery Disease

Objective: Cardiovascular disease is the principal cause of death in the United States, Europe, and much of Asia. Previous studies have addressed the possible role of infectious agents in the pathogenesis of atherosclerosis and coronary artery disease(CAD).Recent studies indicate that systemic markers of inflammation can identify subjects at high risk of coronary events. Therefore, it is very necessary to find some unkonwed biological markers of CAD, specially inflammation markers. The purpose of this study is to observe the association of plasma neutrophil elastase (NE) concentration with CAD.Methods: 87 patients scored by Gensini's scores system according CAG were divided into four groups: acute myocardial infarction(AMI) group (n=11), unstable angina pectoris(UAP) group (n=38), stable angina pectoris(SAP) group (n=21) and control group (n=17). Plasma NE concentration were determined by ELISA using ELISA Kit and then compared among the groups. The relationship between NE concentration and Gensini's scores, the relationship between NE concentration and cardiovascular risk factors were also observed.Results:①Plasma NE concentration had no relationship with Gensini's scores(P＞0.05).②Plasma NE concentration had no relationship with the cardiovascular risk factors(P＞0.05).③The difference of plasma NE concentration between every two groups was not statistically significant(P＞0.05).Conclution: These results confirm that NE is not a sensitive inflammation marker of CAD.