Studies On The Chemical Constituents Of Eriophyton Wallichii Benth And Sanguisorba Officinalis L.

This dissertation consisted of three chapters. The first chapter elaborated theprogress of iridoids occurring in plants. The later two chapters respectively elaboratedthe chemical constituents of Eriophyton wallichii Benth. and Sanguisorba officinalisL.The first chapter is a review of the research progress of iridoids occurring inplants, which includes their structure and pharmacology.The second chapter consisted of two parts. The first part is about the chemicalconstituents of methanol extraction from the aerial parts of Eriophyton wallichiiBenth. Seven compounds were isolated and identified. Among them, the compoundsof marrubiin, ursolic acid, cimigoside, 5-deoxyantirrhinoside, 8-epiloganic acid,apigenin 7-(6"-p-coumaroyl)glucoside were firstly reported in this plant. AHPLC-MS~n method was developed for rapid identification of major compounds ofEriophyton wallichii. A total of 8 peaks in the chromatograms were unequivocallydetermined (peaks 1, 8) or tentatively identified (peaks 2-7) based on the detailed UVand tandem mass spectra analysis. Seven components were identified as 8-epiloganicacid (Ⅰ), Quercitrin 3-glucoside-7-(6-p-coumaroyl)glucoside(Ⅱ), ajugoside(Ⅰ)(Ⅲ), Chrysoeriol 7-O-E-p-coumaroyl-3-O-β-D-glucoside (Ⅳ), helichrysoside(Ⅴ), apigenin 2,3-dihydrogen-7-(6"-p-coumaroyl) glucoside (Ⅵ), apigenin7-(6"-p-cournaroyl) glucoside (Ⅶ)。The third chapter elaborated the chemical constituents of methanol extractionfrom Sanguisorba officinalis L, eight compounds were isolated from this plant byrepeat column chromatography over silica gel. These compounds were identified as3,4'-O-dimethylellagic acid, 3,3',4'-O-trimethylellagic acid, 3,4'-O-dimethylellagicacid-4-O-β-D-xyloside, 3β-O-α-L-arabinopyranosyl-19α-hydroxyl-urs-12-en-28-oicacid 28-β-D-glucopyranoside, 3β-[(α-L-arabinopyranosyl)oxy]-urs-11,13(18)-dien-28-oic acidβ-D-glucopyranosyl ester, 3-O-α-L-arabinopyranosyl-urs-12,18(19)-dien-28-oic acidβ-D-glucopyranosyl ester, catechin.