Clinical Effect Observation Of TCM Syndrome Differentiation Treatment On The Adverse Reaction After Taking Oral Typoglycemic Drugs

Purpose:This topic chooses the diabetes patients according to inclusive criteria that have taken oral hypoglycemic drugs to appear the bad responses gastrointestinal tract on foundation of many clinical cases observation. At the same time ,we classify the patients to differentiation types of TCM with the symptoms, the tongue presentation and pulse manifestation, and establish western medicine comparison group. We observes the patients around the treatment the main symptom improvement situation and the alteration of blood glucose, thus to confirm Chinese medicine distinguishes effects a permanent cure this sickness validity, security and the Chinese medicine superiority, and initially discusses its treatment mechanism, thus instructs clinically, the active control blood glucose, delays the illness complication to occur and improves the quality of life.Methods:During the period of March, 2005 to 2006 year in December, we collect 120 examples that appears the gastro-intestinal tract bad reaction after taking oral hypoglycemic drugs, divide into the Chinese native medicine treatment group and the western medicine comparison group. The Chinese native medicine treatment group chooses 100 examples patients, carries on the Chinese medicine different classification .There were 21 patients in weakness of the spleen and stomach, 24 patients in spleen-kidney yang deficiency, 20 patients in despression of liver-qi, 18 patients in damp heat blocking the middle jiao, 17 patients in cold-heat complication. This 100 examples patient keeps the diabetes foundation treatment (diet, movement and oral hypoglycemic drugs and so on), separately gives the Chinese native medicine treatment according to different classification, and must advantage the group 20 examples comparisons with western medicine misapride tablet. Aroundj according to treats is connected the result to carry on the analysis around, treats the curative effect result and the main symptom improvement situation compared with during each group, and observes the alteration of the baseline blood glucose, blood glucose of 2 hours after dietary, HbAlc and so on.Results:After each group of symptoms integral, the baseline blood glucose, blood glucose of 2 hours after dietary, HbAlc, we separately carry on around the treatment and comparisons of each group. Result shows that on the clinical curative effect, the groups of spleen-stomach weakness, despression of liver-qi and cold-heat complication are superior to the group of western medicine(P＜0.05), but there are not significant differencamong the groups of spleen-kidney yang deficiency, damp heat blocking to the middle jiao and the western medicine (P＞0.05).Fasting blood glucose after each group of therapy dreases before therapy, and the curative effect is similar among each groups. Among the control situation of blood glucose of 2 hours after dietary, the effects of the groups of spleen-stomach weakness, despression of liver-qi and cold-heat complication are better than the group of western medicine, also is most remarkable by the curative effect of cold-heat complication group. Among each group of HbA1c, the treatment of spleen-stomach weakness group obviously surpasses the western medicine comparison group.Around before the contrast treatment the symptom integral situation, after the Chinese native medicine various cards group treats the integral comparatively to treat reduces, clinical symptom improvement. The western medicine group except anorexia, diarrhea, vomiting, analexhauting increasing, the rest symptom also has improved. Between the Chinese native medicine various cards group and the western medicine comparison group, we discover that in the symptom improvement of anorexia, the groups of spleen-stomach weakness and damp-heat blocking to the middle jiao obviously surpasse the western medicine group (P＜0.01).In the symptom improvement of stomachache, the group of despression of liver-qi and damp-heat blocking to the middle jiao are better than the western medicine group (P＜0.05). In the symptom improvement of abdominal distension and abdominal pain, the groups of despression of liver-qi and spleen-stomach weakness are superior to the western medicine group (P＜0.05). In the symptom improvement of anal exhaust increasing, the group of despression of liver-qi is better than the western medicine group (P＜0.05). There are no significiant difference on the improvement of nausea and vomiting, constipation (P＞0.05). Conclusion:The clinical curative effect is accurate through the Chinese medicine of observing the syndrome to treat the gastro-intestinal tract bad reaction after taking oral hypoglycemic drugs. And we makes a follow-up visit that discovery not to be easy to recur. Therefore it can improve the symptom, assist the active control blood sugar, reduce the blood glucose fluctuation, delay the illness complication the occurrence, improve patient's survival quality.