Clinical Study Of Islet β-cell Function In Patients With Primary Hyperuricemia And Gout Pedigrees

Objective To investigate the effect of the serum uric acid on isletβ-cell function. Methods The patients and their first-degree relationsfrom 20 primary hyperuricemia and gout pedigrees underwent an oral 75gglucose test(OGTT) and were determined serum uric acid(SUA),60 cases ashyperuricemia and gout group (HG group) who accorded with diagnosis standardwere selected;60 subjects of similar age and sex with HG group in the controlgroup were selected from this locality. They were determined for glucose andinsulin at fasting, 1 hour and 2 hours, serum levels of totalcholesterol(TC),triglyceride(TG),HDL, LDL, apoA₁, apoB, GHbA₁c, serum uricacid(SUA) and creatinine(SCr),and measured for body massindex(BMI),waist/hip ratio(WHR). Modifiedβ-cell function index was usedto evaluate insulin secretion and sensitivity, the homeostasis modelassessment of insulin resistance(HOMA-IR) was used to estimate insulinresistance. Resultsâ‘ 28 subjects were diagnosed with diabetesmellitus(DM), and 14 subjects with impaired glucose tolerance(IGT) and/orimpaired fasting glucose(IFG)(impaired glucose regulation, IGR) werediagnosed in HG group, glucose tolerance and HbA₁c of 18 subjects werenormal;6 subjects were diagnosed with DM and 4 subjects were diagnosed withIGR, glucose tolerance and HbA₁c of 50 subjects were normal;â‘¡Significantlyhigher FINS, PG2h, INS120, MBCI, HOMA-IR in HG group without glucosepathobolism were found compared with those in the control;â‘¢Significantlyhigher FPG, FINS, PG2h, INS120, MBCI, HOMA-IR in HG group were found comparedwith those in the control;â‘£BMI, WHR, SBP, CH, TG, LDL, apoB, Scr in the HG groupwere higher and HDL, apoA₁ were lower than those in the control group;⑤In68 subjects,stratified by means of HbA₁c(5.4%),high HbA₁c group hadsignificantly higher HOMA-IR, MBCI, FINS, BMI, and significantly differenceof SUA was found between high HbA₁c group and lower HbA₁c group;â‘¥SUA is anindependent risk factor of suffering DM/IGR analysed with logistic regression. Conclusions Insulin resistence exists and the isletβ-cellfunction increases compensatively in gout pedigrees patients,hyperuricemia is an important factor affecting the metabolism disorders ofglucose;Decreasing the SUA level could improve insulin resistance andprotect isletβ-cell function, thus can delay occurrence of glucosepatholism.