The Study Of Tissue Doppler Imaging Combining With Adenosine Stress Echocardiography In Diagnosis Of Coronary Artery Disease

Objective: The aims of the study were to assess the value of tissue Doppler imagingby adenosine stress echocardiography in diagnosis of Coronary Artery Disease and todetermine the sensitivity and specificity by the golden criterion of coronaryangiography.Methods: Tissue Doppler imaging adenosine stress echocardiography was performedin 48 suspected patients with Coronary Artery Disease using continuous infusion doseof 140μg/kg/min in 6mins (total dose of 0.8μg/kg). Maximal systolic Left ventricularwall segments motion velocities, accelerations and peak time were measured.Meanwhile, using the two-dimensional echocardiograph to estimate the extent ofventricular wall segments motion abnormalities before and after stresses subjectively.Results: Tissue Doppler imaging adenosine stress echocardiography was positive in24 out of 30 patients with Coronary Artery Disease and 3 out of 18 normal persons.The sensitivity of this test was 80.0% and the specificity was 83.3%. The sensitivity indiagnosis of Coronary Artery Disease with one, two and three-vessel stenosis were66.7%,75% and 100% respectively. Two-dimensional stress echocardiography waspositive in 22 out of 30 patients with Coronary Artery Disease and 5 out of 18 normalpersons. The sensitivity of this test was 73.3% and the specificity was 72.2%. Thesensitivity in diagnosis of Coronary Artery Disease with one, two and three-vesselstenosis were 55.6%,66.7% and 100% respectively.Conclusions: Tissue Doppler imaging adenosine stress echocardiography can besafely performed in suspected CAD patients, with high sensitivity and specificity.Moreover, the side effects in diagnosis of Coronary Artery Disease are minimal. Itwas more objective and accurate than 2-D echocardiography and can be used toscreen patients with CAD.