| objective To investigate the effects of short term therapy of ATRA on proliferationof vascular smooth muscle cells in the injured rabbits carotid artery and the expression ofcdk4.Methods Rabbits were randomly devided into three groups: pseudooperationgroup, control group and ATRA treated group, pseudooperation group were treated ascontrol group, they.were fed with chlesterol-enriched diet but their carotid artery intimawere not injured; control group were fed with chlesterol-enriched diet and their carotidartery intima were injured; ATRA treated group were fed with chesterol-enriched dietsupplemented by ATRA for 4 weeks and their carotid artery intima were injured; then thecarotid artery were harvested for histomorphometry observation anda-actin and cdk4immunohistochemistry analysis after the carotid artery intima were injured 1week and 4weeks.Results In control group there were significantly lower than ATRA-treated groupin the expression of a-actin and significantly high in the expression of cdk4 in oneweek, and there were distinct neointimal formation and narrow luminal area in fourweeks; ATRA-treated can decrease atherosclerotic lesion in rabbits carotid artery intima.Conclusion the results indicate that ATRA treatment can inhibit atherosleroticprogression by inhibiting the proliferation of vascular smooth muscle cells. Themachanism may be related to inhibition of phenotypic swith of VSMC and activation ofCDK4 in vascular smooth muscle cells. |
PDF Full Text Request