The Effects Of Remifentanil In Various Target Plasma Concentrations On Hemodynamic Response To Tracheal Intubation Induced With Sevoflurane

Objective: To compare the effects of remifentanil in various target plasmaconcentrations on hemodynamic and BIS response to tracheal intubation induced withsevoflurane.Methods:Fifty ASAⅠ-Ⅱpatients aged＜65yr undergoing electivesurgery under general anesthesia were enrolled in this study.The patients wereunpremedicated. Anesthesia was induced with remifentanil given by TCI andsevoflurane inhalation simultaneously.The patients were randomized to receiveremifentanil at a fixed target plasma concentration of 0,2,4,6 or 8ng/ml(group R0,R2,R4,R6,R8).Sevoflurane was started at 3%.Trachea was intubated followingintravenous rocuronium when the BIS of patients was 65.Results:ET-sevof wasdecreased significantly from group R2 to R6 (P＜0.05).MAP increased significantlyfor 2 rain after intubation in group R0 and R2.But MAP did not changed in groupR4 after intubation.Conclusion: remifentanil given by TCI simultaneously potentiatessevoflurane for induction of anesthesia.Sevoflurane(3%vol) in the presence ofplasma remifentanil concentration of 4 ng/ml can effectively attenuate the intubationresponse.