Biocompatibility Of The Implantable Glucose Sensor

The worldwide incidence of diabetes is growing rapidly. Diabetes is estimated as the third leading cause of death. Continuous glucose monitoring is a tool can provide tight insulin therapy to reduce complications.Despite the increasing efforts over the last 3 decades to develop an implantable subcutaneous sensor, a reliable long-term continuous monitoring is yet to be achieved. The in vivo failure of implantable glucose sensors for diabetics is thought to be a result of three different biocompatibility issues: (1) biofouling of implanted sensors. (2) perturbation of key analytes consumed and produced by cells surrounding an implanted sensor. (3) the inflammatory response toward an implanted sensor, In the biomaterial research field, An expansion of the concept of biocompatibility is necessary, to address not only the biosafety issue, the exclusion of cytotoxic and other deleterious effects of biomaterials, but also the biofunction, which concerns the applied biomaterial. Careful scrutiny of this concept leads to the conclusion that relevant test systems for biofunction must centre on human cells, studied under conditions relevant to the situation in the living organism for which the medical device has been constructed.This paper gives some different methods from outer coating, implanting method and position to improve biocompatibility of subcutaneous implanted glucose sensors. And evaluation of biocompatibility of outer coating silicone rubber. Give a method of biocompatibility studying to future work. The article also points out the problems in application and the direction in the future.