The Clinical Curative Effect Observation Of Chinese Medicine By Iontophoresis On Assisted Treating In Chronic Cough Of Postnasal Drip Syndrome In Children

Objectives:By treating the children in chronic cough of postnasal drip syndrome (PNDs) with XiangDan injection by iontophoresis through acupuncture points on the basis of decoction herbalmedicine to observe the changes of signs and symptoms before and after treatment andcompare the clinical effect with control groups to search for a more efficient way to improveclinical effect.Methods:According to the standard of PNDs in the Guideline for Diagnosis of Cough andTreatment established by the asthma panel of the pneumologie branch of Chinese MedicalUnion in 2005, sixty children suffering from chronic cough of PNDs were randomly dividedinto the Treatment Group A and the Control Groups B and C in which there are 20 ratesrespectively. Both of the Treatment Group A and the Control Group B were andled withdecoction of my tutor who designs the prescription—Freeing opening and relieving coughprescription. Then Group A receives therapy of Xiang Dan injection by iontophoresis throughacupuncture points. Additionally, the patients in Group B were given Lorata-dine pills orally,and the Group C was treated with Budesonide aqueous nasal spray as well as Lorata-dine pillsorally combined with relieving cough. There is no significant deviation between the data ofthree groups with Homogeneity-of-variance Test (P＞0.05). Then the therapeutic groupreceived therapy of iontophoresis once a day, 20minutes each time and 7 times constituted acourse of treatment and 2 courses were given. There are 5 cases using medicine irregularlyand 2 cases failed to follow up during lamivudine therapy and there are 53 cases ofinformation completely with 18 cases in Group A, 20 in Group B, 15 in Group C after the endof treatment. Then the curative effects among three groups were compared.Result:1. the side of total effective rate: The total of effective rate of Group A was 94.4% and that of Group B was 85% and C was 80%. There was significant difference between Group Aand Group C(P＜0.05) and no significant difference between Group A and B as well as GroupB and C(P＞0.05).2. comparing the scores of symptomatic with those of physical sign: There wassignificant difference in comparison of scores of before and after therapy in each group(P＜0.01) and after the treatments the scores difference was Remarkable between Group A andC(P＜0.01) and there was significant difference between Group A and B(P＜0.05).3. following up after one month of the end of treatment: There was no significantdifference in the total effective rate between the time of the following up after one month ofthe end of treatment and the very time of the therapy finished in Group A as well asB(P＞0.05). Otherwise, significant difference existed in Group C (P＜0.05), which indicatedthat the symptomatic in Group C often recurred when the treatment was stopped. It is relatedto the period of treatment that was short (only 2 weeks). As the number of cases is small, theconclusion can just be treated as reference. There was Remarkbale difference in the curativeeffect of symptomatic recovery of nasal obstruction between the treatment group and thecontrol groups B and C (P＜0.01), which indicated that the effect of iontophoresis waspredominant in the nasal obstruction. As regards the effect of rhinocnesmus, there wassignificant difference between Group B and A, as well as between Group B and C(P＜0.05),which improved that efficacy in rhinocnesmus symptomatic of Group B with therapeuticmethods of Lorata-dine pills on the basis of decoction herbal was more stable than the othertwo groups.Conclusion:The clinical effect is good to treat chronic cough of PNDs in children withiontophoresis through acupuncture points on the basis of decoction herbal medicine. Owing totherapy with compound injection of red sage root by iontophoresis, delivery can improvelocal microcirculation quickly and alleviate nasal mucosa's hyperemia more rapidly toreliving nasal obstruction effectively, reducing secretion of nasopharynx, meanwhile herbalmedicine percolating the lung to open the orifices as well as conditioning prognosis, whichcan control the symptomatic of cough better and by which the patients' conditions were stableafter treatment and recurred less. There was no adverse reactions during this therapy afterobserving. The therapy of being operated by iontophoresis through acupuncture points is easy; meanwhile, children don't sufer affliction and compliance of children is good, so it can beregarded as therapeutic methods of topical administration in chronic cough of PNDs inchildren in clinical applications.