| Objectives: Cerebral palsy (CP) is non-progressive abnormal control of movement orposture. It is the most common cause of physical disability in childhood with mentalretardation, abnormal behavior and sensuality. The etiology of CP is very complicated,and there are about 15-20％CP patients no clearly prevalence. In order to prevent CPeffectively and improve the children's life quality, the etiology of CP becomes moreand more important. The purpose of this study was to investigate the risk factors ofCP.Methods: According to the CP diagnosis standard, exclusion criteria for CP includedprogressive damage to the developing brain, metabolic, degenerative and infectiousdisorders. CP was classified into eight subtypes. The following items were recodedfor each patients and control, which including gender, born place and season ofgestational age(GA)and birth weight (BW), singleton and multiple births, way ofdelivery, amniotic fluid, umbilical cord, asphyxia, age of mothers and complicationof pregnancy, encephalopathy, sepsis and shock of newborn, injury of brain andsocio-economic status (SES) of parents. Results were dealt with computer software(SPSS 11.5). Logistic Regression analysis and chi-square test was used to assess the different data and P＜0.05 was considered to be statistically significant.Results: 1. The results of births: The number of boys with CP is more than girls. Theratio is 3.2:1. There is statistically significant difference. The highest number of CPbirths occurred in summer. The number of CP births occurred in autumn is less thanothers, and the birth number is highest in autumn in control group (87/204, 42.6％).The ratio of birth hospital in country is 66.19％in CP group and 48％in control groupabout equal to labor in city general hospital. The odds ratio of birth in city generalhospital is 0.415 (95％CI, 0.263-0.655, P＜0.0001 ). There are 277 children with highrisk factors in CP patients; the ratio is 78.1％(277/355). There are 123 (34.6％,123/355) cases have more than two risk factors. There are 69 (19.43％, 69/355) CPcases no obvious high risk factor. 2. The relation between CP and GA and BW: Theratio of premature in CP group is 43.1％, among them GA less than 34W is 39.1％, theodds ratio is 3.362(95％CI, 2.299-4.916, P＜0.001). The birth weight odds ratio is2.086, P＜0.001. 3. The relation between CP and asphyxia: The number of asphyxiain CP group is 86 (24.2％), but only 6 (2.9％) in control group. The odds ratio is 8.945(95％CI 2.319-34.495, P＜0.01). 4. The relation between CP and the complication ofpregnancy: The number of the complication of pregnancy is 62 (17.4％) in CP groupand 7 (3.43％) in control group, the odds ratio is 6.682 (95％CI, 2.293-20.538,P＜0.01). 5. The results of neonatal sepsis: The odds ratio of neonatal sepsis is 6.893.(95％CI, 2.283-20.548, P＜0.05). 6. The relation between CP and socio-economicstatus (SES) of parents: The ratio of farmer in CP group is more than control group(P＜0.05).Conclusions: There are several high risk factors correlated with CP, which includingdelivery in country hospital, premature, multiple births, asphyxia, older mother,complication of pregnancy and sepsis and as well as SES of parents.
|
PDF Full Text Request