The Study Of Relationship Between Single Nucleotide Polymorphisms Of Of Phosphodiesterase 4D Gene And Cerebral Infarction

Background and objectiveA suggested role of PDE4D in stroke pathogenesis is that PDE4Dexpression can influence the second messenger c-AMP, an importantsignal transduction moleculer with many cellular functions, includingmooth muscle cell proliferation. Recent Icelandic studies havedemonstrated linkage for common forms of stroke to chromosome 5q12and association between phosphodiesterase4D (PDE4D) and ischemicstroke. At present,the association between PDE4D gene and cerebralinfarction are arguably.We examined whether the ploymorphisms ofrs918592 and rs33395 related with the incidence of cerebral infarction inHan population of hunan, China.MethodsThe study population was comprised of 131 unrelated Chinese CIpatients and 112 healthy individuals.The PDE4D genotypes weredetermined by PCR and digestion by specific restriction enzymesResults1. In the study polulation, the frequencies of rs918592 genotypes are:AA34.8%, AG44.1%, GG21.1, the frequencies of A/G allelic are56.8% and 43.2%, the frequencies of rs33395 genotypes are:CC16.9%, CT48.5%, TT34.6%, the frequencies of C/T allelic are41.2% and 58.8%.2. Rs918592 polymorphism of PDE4D gene revealed no significantdifference of genotype and allelic distribution in CI patients andcontrols. In the IS group, there is no obvious difference observed inblood fat among the three genotypes(AA,AG,GG). 3. Rs33395 polymorphism of PDE4D gene revealed no significantdifference of genotype and allelic distribution in CI patients andcontrols. In the CI group, there is no obvious difference observed inblood fat among the three genotypes(CC, CT, TT).Conclusions1. Our study report firstly that SNP rs918592 and rs33395 of PDE4Dgene were found in Han population of Hunan, China.2. Our results suggest no significant association between polyphismrs918592 and rs33395 of PDE4D gene and cerebral infarction.3. Our results suggest no significant association between polyphismrs918592 and rs33395 of PDE4D gene and blood fat metabolism andblood sugar metabolism.