Effect Of Microcirculation On Rats For Panaxoside RG2

Object The model of the rat mesentery,cerebral pia mater and mouse cerebral piamater microcirculation disturbance was set up by high polymer dextran and adrenaline.It proved the effect that Panaxoside Rg₂ cyclodextrin inclusion compound to improveminicirculation and offer the base of pharmacology to treat the microcirculationdisturbance disease.Methods The rat was injected high polymer dextran or adrenaline intravenousto set up the model of microcirculation disturbance. To expose Mesentery orCerebral pin mater before the rats was poded, and g e Panaxoside Rg₂ cyclodextrininclusion compound from duodenum (dosage: 50, 100, 200mg/kg)or from vein(dosage: 2.5,5,10 mg/kg). The mouse injected adrenaline intravenously afterinjected Panaxoside Rg₂ cyclodextrin inclusion compound (dosage: 5,5,20 mg/kg)to different observe the changes of Sucquet's canal wrap,blood flow rate andthe number of net focal point in differ time under the microscope.Result Panaxoside Rg₂ cyclodextrin inclusion compound can conspicuous depressantdepressant effect that the Sucquet's canal warp diminution of the rat mesentery andcerebral pia mater, step down the blood floe rate and decrease the number of net focalpoint's. But for the mouse cerebral pia mater, it can expand the Sucquet's canal warp,accelerate the blood floe rate and increase the the nember of net focal point. Therehave dose-effect relationship for the effect of above-mentioned in extent.Conclusion The Panaxoside Rg₂ cyclodextrin inclusion compound can conspicuousimproved the effect that the microcirculation disturbance of the rat mesentery,cerebral pia mater and mouse cerebral pia mater. And obviously improved the effect that thedisturbance of adrenaline and the normal mouse cerebral pia mater...