Research On The Brain Tissue Optical Model By Monte Carlo And Phantom Simulation

In vivo and mini-invasive determination of tissue parameters is an important area in tissue optics. In this paper, an algorithm theory for determinining the scattering coefficient of brain tissue was developed by Monte Carlo simulations and Phantom experiments, and the algorithm theory can be used to determine scattering coefficient of brain tissue and to be used in some reseach such as probe orientation location in the brain surgery operation.The research focused on three parts: 1. The photon distribution in the tissue was studied by Monte Carlo simulations, and the 2-dimensional images of photo distribution are constructed, which display the relationship between photon distribution and scattering coefficient of brain tissue 2. Based on the photo distribution images of brain tissue, the Look Ahead Distance (LAD) of optical probe in the brain tissue was explored by Monte Carlo simulations, and the empirical formula of LAD was obtained by Monte Carlo simulation, LAD is the effective penetration depth for a optical probe in the brain tissue, which was valuable for the measurement on the scattering coefficient algorithm of brain tissue. 3. The algorithm theory for determination of scattering coefficient of brain tissue was developed. Two kinds of simulation models were systematically studied, which were scattering coefficient ascending and descending models.The photon distribution in the simulation model was studied and the relationship between the photon distribution and scattering coefficient of the model was analyzed; The scattering coefficient algorithm was obtained by theory analysis. Finally, the Monte Carlo and Phantom experiments were used to verify the algorithm, and the experiment results showed that the scattering coefficient algorithm can meaure the scattering coefficient of brain tissue realtime and correctly.The scattering coefficient algorithm theory is valuable for the mini-invasive determination of scattering coefficient of brain tissue, and especially for the probe location in the brain surgery operation and the mini-invasive research on the brain tissue, and it will provide an effective theory tool for deeply brain research in the future.