Perfusion CT For The Assessment Of Tumour Vascularity In Renal Carcinoma

Objective: the purpose of our study was to evaluate the correlation between the CT perfusion parameter,the renal carcinoma microvessel density(MVD) and tumor vessel maturation indices(VMI); To determine the feability and value of CT perfusion in assessing tumor neovascularity in renal cell carcinoma.Methods: Twenty-two patients with histologically diagnosed renal cell carcinoma underwent CT perfusion. Blood flow, blood volume, mean transport time and permeability-surface area product was quantitatively calculated for all the lesion, the transverse functional CT map imagine was obtioned. A double-labeling immunohistochemical technique was used to stain CD34 and a-SMA , microvessel density(MVD) and tumor vessel maturation indices(VMI) was calculated.Results:â‘ 22 patients were involved in this study include clear cell carcinoma(n=16),granular cell carcinoma(n=1), chromophobe carcinoma(n=2), papillary carcinoma(n=1), squamous cell carcinoma(n=1),diffusion lymphoma(n=1) ; â‘¡CT perfusion parameter,MVD,VMI varied greadly,heterogeneity was seen in functional map;â‘¢Positively correlation was seen between BF and BV(r=0.673),BF and MTT(r=-0.716);also between BF and MVD(r=0.643) ,BV and MVD(r=0.542);All CT perfusion parameter did not significantly correlate with VMIConcluions:â‘ CT perfusion may be suited to evaluate tumor vascularity in vivo on the basis of the correlation between perfusion parameters and MVD of renal cell carcinoma. Functional CT images may reflect the heterogeneity of tumor angiogenesis.â‘¡CT perfusion can not used to access tumor vessel maturation level, the relationship betweed CT perfusion and VMI needs advanced research.