The Effect Of Granulocyte Colony-stimulating Factor On The Change Of Bone Marrow In Cell Population And Morphology After Cancer Chemotherapy

Object:To observe the effect of granulocyte colony stimulating factor on the change of bone marrow in cell population and morphology after chemotherapy in cancer patients.Methods:A series of 44 evaluable cancer patients were collected and divided into 2 groups randomized.The patients were given G-CSF at a dose of 150μg/body or 300μg/body daily as the study group(27 cases),and the others(17 cases)as the control group.The dates of bone marrow in three different periods after peripheral blood lencocyte count less than 2.5×10~9 were collected and put into observation.Results:(1)G-CSF significantly accelerate recovery time of the total white cell count (WBC)and enhance the recovery velocity of WBC,reduced the number of recovery days to normal.(2)The neutrophilic leukocyte initiate proliferation and maturation process at the stage from myelocyte to metamyelocyte in study group.(3)In study group interior,no relationship between the dosage of G-CSF and the proliferation degree of neutrophilic leukocyte were found.(4)Under the incentive of G-CSF,the changes of granulocyte's morphology have its own characteristics.(5)In the course of observation,dyshaematopoiesis wasn't founded.The side effect of G-CSF was febrile and bone ache.It's mild and tolerable. Conclusion:(1)G-CSF can stimulate proliferation of neutrophilic leukocyte efficiently and make myelocyte became mature in bone marrow(2)The period acting on the granulocyte by G-CSF is stage from myelocyte to metamyelocyte.(3)Within the test dose range,no evidence showed the granulocyte argument was related with drug dose.(4)The morphology change of the internal environment of bone marrow under incentive of G-CSF has its own characteristics.