The Study Of The Expression And Clinical Significance Of COX-2 And E-cadherin In Pancreatic Carcinoma

Objective: To investigate the relationship between the expression of E-cad, COX-2 and the clinic pathological characteristics, discuss the development regulation and clinical significance in pancreatic carcinoma patients: Methods: Immunohisto-chemistry method was used to detect the expression of E-cad and COX-2 in 56 pancreatic cancer tissues, 12 cases metastasis lymph node from 56 patients and 10 normal pancreatic tissues. The relationships between the expressions and clinic pathological characteristics, survival rate were analyzed. Results: The expression ratios of E-cad in normal pancreatic tissues, pancreatic carcinoma and lymph node with metastasis were 80%, 37.5%, 16.7% respectively, The expression ratios of E-cad pancreatic carcinoma and lymph node with metastasis were lower than that in normal pancreatic tissue (P<0. 01), that in well-differentiated, moderately-differentiated and poorly-differentiated pancreatic carcinomas tissues were decreased orderly. The significant differences were observed between poorly-differentiated pancreatic carcinoma tissues and other two groups(P<0. 05), The expression of E-cad in pancreatic carcinomas was significantly associated with the TNM stage, histological grade, ratio of one year survival and lymph node metastasis (P<0. 05). The expression ratios of COX-2 in normal pancreatic tissues, pancreatic carcinoma and lymph node with metastasis were 10%, 78.6%, 83.3% respectively, The expressions rate of COX-2 in pancreatic carcinoma and lymph node with metastasis were higher than that in normal pancreatic tissue(P<0.01), that in well-differentiated, moderately-differentiated and poorly-differentiated pancreatic carcinomas tissues were increased in orderly. The significant differences were observed between poorly-differentiated pancreatic carcinoma tissues and other two groups (P<0.05). The expression ratio of E-cad in pancreatic carcinomas was significantly associated with the TNM stage, histological grade, ratio of one year survival and lymph node metastasis (P<0.05). Contingency coefficient was observed between expression of E-cad and COX-2 in pancreatic carcinoma tissues (r=0.367). Conclusion: The abnormal expression of E-cad and COX-2 were related to carcinogenesis, metastasis and prognosis in pancreatic carcinoma,, contingency coefficient was observed between both, combined analysis concerning both may be a useful predictor of metastasis and prognosis in human pancreatic cancer.