Effects Of FLAG Regimen In Treatment Refractory And Relapsed Acute Myeloid Leukemia

Objective:To investigate the therapeutic effects,time of hematopoietic depression and side effects of FLAG regimen for refractory and relapsed Acute Myeloid Leukemia (AML).Methods:13 cases(17 times)with refractory and relapsed AML were treated with Fludarabine 30mg/m~2/d and Ara-c 2g/m~2/d for 5 days,and granulocyte colony stimulating factor G-CSF 300μg/d from day 0 till neutrophil recovery(ANC≥1×10~9/L).13 patients were 8 males and 5 females.The median age was 41.8 years(range 28-67).It includes 5 relapsed AML patients and 8 refractory AML patients.Results:Of the 17 times,11 showed response to therapy;the rate of complete remission was 35.3% (6/17);the rate of partial remission was 29.4%(5/17)and the overall response rate was 64.7%.Main toxicities were gastrointestinal side effects,myelosupression and the function of liver was lightly damaged.Neutropenia begin at the time of 5-12 days after regimen initiating and last 7-34 days,thrombocytopenia begin at the time of 5-13 days and last 8-30 days.Conclusions:In our experience,FLAG regimen shows obvious effects for refractory and relapsed AML.Most patients gain chance for hematopoietic stem cell transplantation.Hemotological and nonhemotological toxicities is acceptable.