Study Of QUBAITANG And Ultrasound In Treating Vulvar Lichen Sclerosus

Objective: To observe the effect of QUBAITANG(QBT) in treating lichen sclerosusof the female vulva and to investigate its mechanism. Methods: 1.Clinic study: 60 femalepatients with vulvar lichen sclerosus(VLS) were divided into 2 groups randomly: 30 caseswere treated with ultrasound topically and QBT oral as the treatment group, 30 cases weretreated with ultrasound only. In addition, 30 healthy women were selected as control group.Observing the changes of clinical symptoms, curative ratio, recurrence, immunity's signs(Tcell subgroup CD₃⁺, CD₄⁺, CD₈⁺, CD₄⁺/CD₈⁺ of peripheral blood), humoral immunity(IgG,IgA, IgM), and the anti-oxidation effect before and after treatment (SOD and MDA ofperipheral blood). 2. Experimental study: 40 SD female rats were divided into 3 groupsrandomly, there were 15 rats in the group of Yin-diffiency of the Liver and Kidney (modelgroup) and normal control group respectively, 10 rats in QBT treating group. The controlrats were fed freely, the others were made by means of long irritation. After making surethat the model was made successfully, QBT was given to the treating rats from the secondday, while the rats of normal and model group were given distilled water as control. After 3weeks, CD₃⁺, CD₄⁺, CD₈⁺, CD₄⁺/CD₈⁺, IgG, IgA, IgM, SOD and MDA of peripheralblood were tested. Results: 1. compared to the control group, the total effective rate of thetreatment group were no significant difference (p＞0.05), yet the rate of recurrence wasobviously lower(p＜0.05).2. Clinical symptoms improved in the treatment group. Therewas significant difference compare to the control group (p＜0.05). 3. The patients had low CD₄⁺/CD₈⁺ ratio, IgG, SOD and high MDA. QBT could improve them and there wereobviously difference between the treatment and the control ones after they had been treated(p＜0.05). The experimental results showed QBT could highly improve the CD₄⁺/CD₈⁺ ratio,IgG, SOD and MDA's level of the rats of Yin-diffiency of the Liver and Kidney (p＜0.05).Conclusion: QBT can improve the clinical symptoms and lower recurrence ratio of thepatients with VLS remarkably. It has such merits: adjust the immunity turbulence andanti-oxidation effect.