The Study Of Interaction Between Oxidative Stress And Atherosclerosis In Maintenance Hemodialysis(MHD) Patients

Objective: To analyze the levels of several markers of oxidative stress in MHD patients with cardiovascular disease, and then to characterize the relationship between oxidative stress and atherosclerosis in MHD patients,Methods: 53 MHD patients were entered into study. The patients were divided into two groups, group A: the patients with positive history of atherosclerotic disease (n=21), group B: the patients without positive history of atherosclerotic disease (n=32).There are 20 health persons in control group. Serum levels of Vitamin E, malondialdehyde(MDA), advanced oxidation protein product(AOPP), superoxide dismutase(SOD), oxidized low-density lipoprotein(ox-LDL), and microinflammation cytokines C-reactive protein(CRP) were measured in A, B and control groups . All serum markers of oxidative stress and CRP noted above were measured again in patients by oral VitE(400mg/d ) after 6 weeks and the results were analyzed.Results: Levels of MDA,AOPP,ox-LDL,CRP were significantly higher in MHD patients than in healthy controls(p<0.01). VitE concentration and the activity of SOD in MHD patients were dramatically lower than those in controls respectively. MDA,AOPP,ox-LDL and CRP significantly increased in group A Compared to group B. Serum VitE levels and the activity of SOD in group A were lower than group B(p<0.05).There were no significant difference about the other correlation factors: blood fat, blood pressure, age, the incidence rate of diabetes. AOPP,MDA,and CRP in all MHD patients were decreased by oral VitE after 6 weeks (p<0.05) and VitE,SOD were increased(p<0.05).There was no significant change on ox-LDL.Conclusions: The level of oxidative stress in MHD patients with cardiovascular disease is higher than those without, and there were no significant difference about the other correlation factors of cardiovascular disease. These results indicate the oxidative stress may be a factor in accelerated atherosclerotic disease in MHD patients. Oxidative stress in MHD patients was ameliorate by VitE.