Correlation Of EphA2 Expression With Tumor Angiogenesis In Human Bladder Neoplasms

Objective to evaluate effect of EphA2 on differentiation and tumorangiogenesis in bladder neoplasmas.Methods EphA2, VEGF expression and MVD were investigated byimmunohistochemistry in 47 patients with bladder transitional cellcarcinoma. In addition, 10 normal bladder tissue samples were obtained.Results EphA2 expression was positive in 28 of the 47 patients,whereas negative in all normal samples(x2=11.504,p〈O.O1). Correlationwas observed between EphA2 expression and poor degree of tumordifferentiation (trend test x2=4.55,p〈O.05). Value of MVD was 30.35±1.45 and 25.55±1.75 in EphA2 positive and negative tumor tissuesrespectively. Numbers of VEGF positive was 17 and 5 in EphA2 positiveand negative tumor tissues respectively. Correlation was observedbetween EphA2 expression and MVD,VEGF(t=20.75, p〈0.01; x2=5.379, p〈0.05).Conclusions EphA2 has effect on differentiaton and tumorangiogenesis in bladder transitional cell carcinoma. Data indicatespotential role for EphA2 activation in VEGF-dependent tumorangiogenesis. endothelial growth factor; Neoplasms, vascular tissue...