Observation On Therapy Of Clopidogrel And Aspirin On Elder Patients With Stable Atherosclerotic

Objective: To evaluate the effect and safety of anti-thrombus therapy on elder patients by observing and analyzing the platelet aggregation rate, Plasma thrombus density and bad impacts after the therapy by Clopidogrel and Aspirin on elder patients with stable atherosclerotic.Methods: To pick up 53 patients with stable atherosclerotic who didn't have anti-thrombus therapy in past one month, inside 43 male and 10 female from 72 years old to 90 years old and average age is 78.1±4.1. The total 53 patients were divided at random into Clopidogrel group and Aspirin group, the Clopidogrel group includes 27 and the rest 26 were in Aspirin group. The two groups were therapy respectively by Clopidogrel 75 mg·d-1 , 14 days and Aspirin 100mg·d-1,14 days. Their routine blood, hematology & biochemistry, platelet aggregation (ADP and Arachidonic acid (AA) revulsants) and plasma thrombus B2(TXB2density)were measured before and after the period of treatment. Another Contrast group consists of 21 healthy (17 male and 4 female age 42~63 and mean 52.1±7.2). The statistics data was processed by SPSS13.0 and X2 verification, the before-after data was inspected by partnership T. Variance analysis was applied for comparing the three groups, the comparison between the two medicines was tested by double sample T, inhibition rate was described by percentile. P<0.05 shows statistic variance and P<0.01 means significant statistic variance.Results: The two therapy groups are cmparable on same conditions, 1 patient withdraw in the period due to tetter, the variance of bad impact in the two groups doesn't have statistic significance. There was no remarkable change on measured parameters excepting platelet count in Aspirin group decreased slightly. The platelet aggregation rates of the two therapy groups were higher than Contrast group and TXB2 density was similar as Contrast group before therapy, after therapy with anti-thrombus, all parameters were observed to be close or lower than the health group. Clopidogrel and Aspirin can lower remarkably platelet aggregation rate and Plasma thrombus density, Clopidogrel is better at inhibiting platelet aggregation rate induced by ADP and Aspirin is better on inhibiting platelet aggregation rate induced by AA and TXB2 density.Conclusion: To elder patient, 1. To therapy with Clopidogrel or Aspirin in short term is safe. 2. Positive anti-thrombus therapy is needed for stable atherosclerotic. 3. It is verified that Clopidogrel and Aspirin function on anti-thrombus. 4. Evaluation on effect of Clopidogrel and Aspirin on anti-thrombus is different under different criteria.