The Relationship Between The Over Expressions Of TFF3,iNOS,ERK2 And Helicobacter Pylori Infection In Gastric Cancer And Precancerous Lesions

Objective:To explore the relationship of trefoil factor 3,inducible nitric oxide synthase,extracellular regulated protein kinases 2 and Helicobacter pylori(Hp)infection in the pathogenesis of gastric cancer.Methods:The expressions of TFF3,iNOS,ERK2 were determined by immunohistochemical method in 130 gastric specimens including 30 cases of chronic superficial gastritis,30 cases of intestinal metaplasia,30 cases of dysplasia and 40 cases of gastric carcinomas.Results:In contral group with chronic superficial gastritis,precancerous group,and gastri carcinoma group,the expression levels of TFF3,iNOS,ERK2 had a increasing tendency(P＜0.05).The expressions of them were significantly related with lymph node metastasis and differentiation degree(P＜0.05),but not with histologic type,depth of invasion,distant metastasis and TNM Staging.The expression of TFF3,iNOS,ERK2 in Hp positive group were significantly higher than that in negative group.(P＜0.05)Conclusion:The expression of TFF3,iNOS,ERK2 were up-regulated in the carcinogenesis of gastric carcinoma.Hp infection may play a key role in the development of gastric carcinoma.