Correlated Study Between Hyperuricemia And Leptin Gene Polymorphisms

Objective:to analyze the relationship of hyperuricemia with biochemicals,body common items,insulin,leptin and leptin gene polymer-phism(G2548A),to explore the possible factors and susceptible genes among males.Methods:A case-control study was conducted with 146 males cases of hyperuricemia and 176 males as controls,body blood pressure and biochemical variable were measured and dietary,lifestyle and diseases history were conducted face-to-face investigation.Using DNA sample to detect leptin gene G2548A polymorphism by the methods of PCR-RFLP.Results:1)Compared to normouricemic subjects,hyperuricemic subjects had significantly greater body mass index and WHR,higher blood pressure,glucose,blood lipid concentrations,leptin and INS and HOMA-IR were significant higher(p＜0.05),especially BMI,WHR,DBP,TG, TC(p＜0.001),but ISI was lower than case-control.Hyperuricemic subjects had significantly higher frequency of obesity,hypertension and dyslipidemia(P＜0.01).2) There was significance difference in frequencies of allelein G-2548A polymorphism between hyperuricemia and control group(x~2=7.57,P＜0.01).Individuals with AA genotype showed higher fasting leptin,INS,HOMA-IR than those with GG genotype (P＜0.05).3)Logistic regression analyses showed that SBP,DBP,TG,INS,high Beer intake and purine intake were the risks of hyperuricemia.Conclusion:1)Obesity, hypertension,dyslipidemia and arteriosclerosis were closed related to hyperuricemia. Hyperleptin and insulin resistance may be the basic of these diseases;2)Beer,wine and purine played a significant role in increasing serum uric acid level.For prevention and treating hyperuricemia,people need to decrease the intaking of alcohol and purine;3) Leptin gene polymorphism G-2548A is significantly correlatioed with the hyperuricemia. A allele of leptin may be a genetic factor that may contribute to individual susceptibility for hyperuricemia.